Palliser Gareth Martyn, Fraser Lorna K, Mooney Kate E, Jarvis Stuart W
Department of Health Sciences, University of York, York, United Kingdom.
Cicely Saunders Institute, King's College London, London, United Kingdom.
PLoS One. 2025 Sep 8;20(9):e0306677. doi: 10.1371/journal.pone.0306677. eCollection 2025.
Previous studies have shown associations between specific limiting longstanding illnesses and mental health difficulties using cross-sectional studies in the UK. This study explored the association between having any limiting longstanding illness and serious psychological distress or of currently receiving treatment for depression or serious anxiety at age 17 years.
A secondary analysis of the UK Millennium Cohort Study was conducted. Outcome measures were dichotomised responses from the self-administered Kessler-6 questionnaire for nonspecific psychological distress, and self-reported current treatment for depression or serious anxiety. Limiting longstanding illness data and covariates were taken from questionnaires with parents and adolescents, from birth up to age 17 years. Data were analysed using multiple binary logistic regression, first using complete-case analysis, and then using multiple imputation using chained equations.
Adolescents with a history of limiting longstanding illness were at an increased odds of both serious psychological distress (odds ratio = 1.53, 95%CI = 1.27-1.86) and self-reporting currently receiving treatment for depression or serious anxiety at age 17 years (odds ratio = 3.02, 95%CI 2.24-4.07).
Children and young people with a limiting longstanding illness are at increased risk of having serious psychological distress, depression, and serious anxiety. Practitioners should be aware of this and routine screening for psychological distress, plus additional preventative support, may be beneficial.
先前的研究利用英国的横断面研究表明特定的长期限制性生活疾病与心理健康问题之间存在关联。本研究探讨了患有任何长期限制性生活疾病与17岁时出现严重心理困扰或目前正在接受抑郁症或严重焦虑症治疗之间的关联。
对英国千禧队列研究进行了二次分析。结局指标是来自凯斯勒6项自评问卷中关于非特异性心理困扰的二分法回答,以及自我报告的目前抑郁症或严重焦虑症治疗情况。长期限制性生活疾病数据和协变量取自从出生到17岁期间对父母和青少年的问卷调查。数据首先使用完全病例分析进行多重二元逻辑回归分析,然后使用链式方程进行多重插补分析。
有长期限制性生活疾病史的青少年出现严重心理困扰的几率增加(优势比=1.53,95%置信区间=1.27-1.86),且在17岁时自我报告目前正在接受抑郁症或严重焦虑症治疗的几率也增加(优势比=3.02,95%置信区间2.24-4.07)。
患有长期限制性生活疾病的儿童和年轻人出现严重心理困扰、抑郁症和严重焦虑症的风险增加。从业者应意识到这一点,对心理困扰进行常规筛查以及提供额外的预防支持可能会有所帮助。