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舌黏膜移植治疗输尿管狭窄手术后复发性肾出血:一例报告

Lingual mucosal graft treatment for recurrent renal bleeding after ureteral stricture surgery: A case report.

作者信息

Yang Longyuhe, Wang Yueqiang, Yang Jianbing, Zhao Yunliang, Ma Zhen, Zhang Zhigang

机构信息

Urology Department, Southern Central Hospital of Yunnan Province (First People's Hospital of Honghe State), Mengzi, Yunnan Province, China.

Anesthesiology Department, Southern Central Hospital of Yunnan Province (First People's Hospital of Honghe State), Mengzi, Yunnan Province, China.

出版信息

Medicine (Baltimore). 2025 Sep 5;104(36):e42384. doi: 10.1097/MD.0000000000042384.

Abstract

RATIONALE

Ureteral stricture is a complex urological condition often requiring surgical intervention. Autologous tissue grafts, such as lingual mucosa, have emerged as a promising option for reconstruction due to their favorable biocompatibility and vascularity. However, reports on complications associated with these techniques remain limited.

PATIENT CONCERNS

A 59-year-old male with a history of bilateral kidney stones, chronic renal failure, hypertension, and multiple prior ureteral surgeries presented with left ureteral obstruction and severe hydronephrosis. He had been on regular dialysis and previously underwent several endoscopic and percutaneous stone procedures.

DIAGNOSES

Preoperative imaging confirmed a long-segment stricture in the upper left ureter accompanied by significant hydronephrosis and impaired renal function.

INTERVENTIONS

The patient underwent laparoscopic resection of the strictured segment followed by ureteroplasty using an autologous lingual mucosal graft. A double-J stent was placed, and the graft was secured with absorbable sutures and wrapped with omentum.

OUTCOMES

Postoperatively, the patient experienced 2 episodes of renal hemorrhage, likely exacerbated by anticoagulation during dialysis and underlying vascular fragility. After multidisciplinary management, including cessation of heparinized dialysis and transition to non-anticoagulant therapies, the bleeding resolved. Three-month follow-up showed patent ureter, resolved hydronephrosis, stable renal function, and no recurrence of symptoms.

LESSONS

Lingual mucosal graft ureteroplasty is a viable option for complex ureteral strictures, but careful patient selection is critical - particularly in those with chronic renal failure on dialysis. Intraoperative techniques to avoid renal pelvic injury and judicious postoperative anticoagulation management are essential to prevent hemorrhage. A multidisciplinary approach and close follow-up are key to successful outcomes.

摘要

原理

输尿管狭窄是一种复杂的泌尿系统疾病,通常需要手术干预。自体组织移植物,如舌黏膜,因其良好的生物相容性和血管化特性,已成为重建手术的一个有前景的选择。然而,关于这些技术相关并发症的报道仍然有限。

患者情况

一名59岁男性,有双侧肾结石、慢性肾衰竭、高血压病史,既往多次接受输尿管手术,现出现左输尿管梗阻和严重肾积水。他一直在定期透析,之前接受过多次内镜和经皮取石手术。

诊断

术前影像学检查证实左输尿管上段存在长段狭窄,伴有明显肾积水和肾功能损害。

干预措施

患者接受了腹腔镜下狭窄段切除术,随后使用自体舌黏膜移植物进行输尿管成形术。放置了双J支架,移植物用可吸收缝线固定,并用网膜包裹。

结果

术后,患者经历了2次肾出血事件,可能是由于透析期间的抗凝治疗和潜在的血管脆性加重所致。经过多学科管理,包括停止肝素化透析并过渡到非抗凝治疗,出血得到解决。三个月的随访显示输尿管通畅,肾积水消退,肾功能稳定,且症状未复发。

经验教训

舌黏膜移植物输尿管成形术是治疗复杂输尿管狭窄的可行选择,但仔细选择患者至关重要——尤其是对于那些正在接受透析的慢性肾衰竭患者。避免肾盂损伤的术中技术和明智的术后抗凝管理对于预防出血至关重要。多学科方法和密切随访是成功治疗的关键。

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