Demir Ulku
Department of Ophthalmology, Inonu University Faculty of Medicine, Malatya, Turkey.
Medicine (Baltimore). 2025 Sep 5;104(36):e44270. doi: 10.1097/MD.0000000000044270.
Uveitis is an inflammation of the anatomical layer, which consists of the iris, ciliary body and choroid. Pediatric uveitis is rare, but tends to be more severe and chronic than in adults. This study aims to evaluate the etiology, clinical features, treatment and complications in pediatric uveitis. In this study, the files of 55 pediatric patients (28 boys and 27 girls) under the age of 18 years who were followed up with the diagnosis of uveitis between January 2016 and November 2024 were retrospectively analyzed. Each patient was evaluated in terms of age, gender, age at onset of uveitis, first vision, last vision, involved eye, follow-up period, etiology, localization, course, treatments, surgical interventions, and complications. The mean ages of boys and girls with uveitis included in the study were 15.1 ± 2.7 and 15.0 ± 2.9, respectively. The mean follow-up period of the patients was 3.9 ± 2.8 (years). The mean age at onset of uveitis was 11.1 ± 2.8 years in boys and 12.2 ± 3.1 years in girls. Uveitis involvement in the right eye was 11 (20%), in the left eye 8 (14.5%) and bilateral involvement was 36 (65.5%). The most common etiological causes were idiopathic (52.7%) and juvenile rheumatoid arthritis (27.3%). The most common types of uveitis were anterior (54.5%) and chronic (74.5%), complications were cataract (36.4%) and posterior synechia (30.9%). At the last examination, best corrected visual acuity was ≤0.1 in 5 (9.1%) right and 3 (5.5%) left eyes, 0.1 to 0.5 in 2 (3.6%) right and 3 (5.5%) left eyes, and ≥0.5 in 48 (87.3%) right and 49 (89.1%) left eyes. The findings showed that 14.5% of patients received local steroid treatment and 85.5% of patients were administered systemic treatment. About 16.4% of patients underwent surgical treatment. In our study, bilateral, chronic and anterior uveitis involvement were observed most frequently. The most common underlying causes were idiopathic and juvenile rheumatoid arthritis, complications were cataract and posterior synechiae. About 85.5% patients received systemic treatment and 16.4% patients' surgical treatment.
葡萄膜炎是指包括虹膜、睫状体和脉络膜在内的解剖层发生的炎症。儿童葡萄膜炎较为罕见，但往往比成人更严重且病程更长。本研究旨在评估儿童葡萄膜炎的病因、临床特征、治疗及并发症。在本研究中，对2016年1月至2024年11月期间诊断为葡萄膜炎并接受随访的55例18岁以下儿童患者（28例男孩和27例女孩）的病历进行了回顾性分析。对每位患者从年龄、性别、葡萄膜炎发病年龄、初诊视力、末次视力、受累眼、随访时间、病因、病变部位、病程、治疗、手术干预及并发症等方面进行评估。纳入研究的葡萄膜炎男孩和女孩的平均年龄分别为15.1±2.7岁和15.0±2.9岁。患者的平均随访时间为3.9±2.8（年）。男孩葡萄膜炎的平均发病年龄为11.1±2.8岁，女孩为12.2±3.1岁。葡萄膜炎累及右眼11例（20%），累及左眼8例（14.5%），双眼受累36例（65.5%）。最常见的病因是特发性（52.7%）和青少年类风湿关节炎（27.3%）。最常见的葡萄膜炎类型是前部葡萄膜炎（54.5%）和慢性葡萄膜炎（74.5%），并发症是白内障（36.4%）和虹膜后粘连（30.9%）。在末次检查时，右眼最佳矫正视力≤0.1的有5例（9.1%），左眼有3例（5.5%）；右眼0.1至0.5的有2例（3.6%），左眼有l3例（5.5%）；右眼≥0.5的有48例（87.3%），左眼有49例（89.1%）。结果显示，14.5%的患者接受了局部类固醇治疗，85.5%的患者接受了全身治疗。约16.4%的患者接受了手术治疗。在我们的研究中，最常观察到的是双侧、慢性和前部葡萄膜炎受累。最常见的潜在病因是特发性和青少年类风湿关节炎，并发症是白内障和虹膜后粘连。约85.5%的患者接受了全身治疗，16.4%的患者接受了手术治疗。
