Resident, Sankara Nethralaya, Chennai, Tamil Nadu, India.
Department of Strabismus and Pediatric Ophthalmology Medical and Vision Research Foundations, Sankara Nethralaya, Chennai, Tamil Nadu, India.
Indian J Ophthalmol. 2023 May;71(5):2158-2161. doi: 10.4103/ijo.IJO_1993_22.
This study aimed to describe visual outcomes in cases of pediatric uveitis in an Indian population and to analyze various factors affecting these outcomes.
Single-center, retrospective chart review of 277 cases of uveitis in patients under the age of 18 years. Variables assessed included age and sex distribution, anatomical location of uveitis, systemic associations, complications, and various treatment strategies used, including long-term immunomodulation and surgical management of complications if required. The main outcome was the final visual acuity.
At the final visit, 51.5% of the eyes showed improvement in the final visual acuity, while vision remained stable in 28.7% and 19.7% of the eyes showed worsening of vision at the final follow-up. A total of 19.4% of patients were blind in at least one eye at the final visit, and 16 patients (5.77%) remained bilaterally blind at the final follow-up. The presence of cataract (p = 0), posterior uveitis (p = 0.005), and retinal detachment (p = 0.014) were the most significant risk factors for predicting worse visual outcomes. More than half (65.7%) of patients reported a complication at some point in their follow-up, and the most common complication was cataract. In total, 50.9% of patients required long-term immunomodulatory therapy.
Pediatric uveitis remains a challenging condition to treat and follow-up, and the visual outcome remains guarded for most patients.
本研究旨在描述印度人群中儿童葡萄膜炎病例的视力结果，并分析影响这些结果的各种因素。
对年龄在 18 岁以下的 277 例葡萄膜炎患者进行单中心回顾性病历分析。评估的变量包括年龄和性别分布、葡萄膜炎的解剖位置、全身相关性、并发症以及所使用的各种治疗策略，包括长期免疫调节和必要时手术治疗并发症。主要结果是最终视力。
在最后一次就诊时，51.5%的眼睛最终视力有所改善，28.7%的眼睛视力保持稳定，19.7%的眼睛最终随访时视力恶化。共有 19.4%的患者至少有一只眼睛在最后一次就诊时失明，16 名患者（5.77%）在最后一次随访时仍双眼失明。白内障的存在（p=0）、后葡萄膜炎（p=0.005）和视网膜脱离（p=0.014）是预测视力结果较差的最重要危险因素。超过一半（65.7%）的患者在随访过程中的某个时间点报告有并发症，最常见的并发症是白内障。总共，50.9%的患者需要长期免疫调节治疗。
儿童葡萄膜炎仍然是一种具有挑战性的疾病，需要进行治疗和随访，大多数患者的视力预后仍不容乐观。
