Zhang Longshu, Chen Ying, Li Hui, Zhou Lirong, Zhou Mengyan, Zhang Xixia
School of Nursing, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China.
Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China.
Medicine (Baltimore). 2025 Sep 5;104(36):e44220. doi: 10.1097/MD.0000000000044220.
To observe the specific changes of auricular points in patients with colorectal polyps (CPs) by auricular assessment. To summarize the clusters of auricular point-specific changes in patients with CPs, and to inform further research into auricular point assisted diagnosis of CPs. A total of 300 participants, with 150 having CPs and 150 having no CPs, were recruited for this case-control study. Auricular assessment included visual inspection, electrical skin resistance measurement, and tenderness testing. The chi-square test and binary logistic regression analysis were used to determine the association between categorical variables. And calculated the sensitivity, specificity, positive predictive value (PPV), and negative predictive value of each acupoint for CPs. Compared with the control group, the polyps group had more significant skin changes in the auricular point "Esophagus," morphological changes in the auricular point "Stomach," color changes in the auricular point "Duodenum," color changes in the auricular point "Shenmen," and shape changes in the auricular point "Rectum" observed on visual examination (P < .05). There was a significant difference in the electrical positive detection rate at 8 auricular acupoints, the "Large Intestine," the "Appendix," the "Small Intestine," the "Kidney," the "Pancreas and Gallbladder," the "Center of Superior Concha," and the "Shenmen" between the 2 groups (P < .05). In the polyps group, 4 auricular acupoints, the "Duodenum," the "Large Intestine," the "Small Intestine," and the "Center of Superior Concha" showed more pronounced tenderness than in the control group. Among these auricular acupoints, the "Large Intestine" also showed the highest PPV of 61.5 on electrical skin resistance measurement, and the highest specificity of 53.3, PPV of 58.3, and negative predictive value of 60.6 on tenderness testing. This study showed that specificity changes in some of the auricular points such as the "Large Intestine," the "Rectum," the "Small Intestine," the "Center of Superior Concha," the "Shenmen," and the "Kidney" are strongly correlated with the prevalence of CPs. Auricular diagnosis has a pre-diagnostic value. It is considered to establish the clusters of auricular point-specific changes to realize the early screening of CPs.
通过耳穴评估观察大肠息肉（CPs）患者耳穴的具体变化。总结CPs患者耳穴特异性变化的聚类情况，为进一步研究耳穴辅助诊断CPs提供依据。本病例对照研究共招募了300名参与者，其中150名患有CPs，150名未患CPs。耳穴评估包括视诊、皮肤电阻测量和压痛测试。采用卡方检验和二元逻辑回归分析来确定分类变量之间的关联。并计算每个穴位对CPs的敏感性、特异性、阳性预测值（PPV）和阴性预测值。与对照组相比，息肉组在视诊时耳穴“食管”的皮肤变化更明显，耳穴“胃”有形态变化，耳穴“十二指肠”有颜色变化，耳穴“神门”有颜色变化，耳穴“直肠”有形态变化（P < .05）。两组在8个耳穴，即“大肠”“阑尾”“小肠”“肾”“胰胆”“上耳甲中心”和“神门”的电阳性检出率有显著差异（P < .05）。在息肉组中，4个耳穴，即“十二指肠”“大肠”“小肠”和“上耳甲中心”的压痛比对照组更明显。在这些耳穴中，“大肠穴”在皮肤电阻测量中的PPV最高，为61.5，在压痛测试中的特异性最高，为53.3，PPV为58.3，阴性预测值为60.6。本研究表明，一些耳穴如“大肠”“直肠”“小肠”“上耳甲中心”“神门”和“肾”的特异性变化与CPs的患病率密切相关。耳穴诊断具有预诊断价值。认为建立耳穴特异性变化的聚类情况以实现CPs的早期筛查。
