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长期发热和严重高钙血症揭示系统性肺外结节病:应吸取的教训

Prolonged Fever and Severe Hypercalcemia Revealing Systemic Extrapulmonary Sarcoidosis: A Lesson to be Learned.

作者信息

Kechaou Ines, Abida Rym, Salah Hamdi Mohamed, Cherif Eya, Ben Hassine Lamia

机构信息

Department B of Internal Medicine, Charles Nicolle's Hospital, Faculty of Medicine, University of Tunis El Manar, Tunisia.

出版信息

Oman Med J. 2025 Mar 31;40(2):e741. doi: 10.5001/omj.2025.10. eCollection 2025 Mar.

Abstract

Sarcoidosis often manifests with pulmonary involvement, making isolated extrapulmonary presentations rare and diagnostically challenging. We present the case of a 43-year-old woman who presented with prolonged fever, deep lymphadenopathy, massive splenomegaly, hepatomegaly, and severe hypercalcemia, mimicking malignancy. The diagnosis of sarcoidosis was established after the failure of anti-tubercular therapy, exclusion of differential diagnosis, and the subsequent development of cutaneous sarcoids. This case highlights the importance of recognizing isolated extrapulmonary pseudo-tumoral presentations of sarcoidosis, which can lead to delayed diagnosis.

摘要

结节病常表现为肺部受累,使得孤立的肺外表现罕见且诊断具有挑战性。我们报告一例43岁女性病例,该患者表现为长期发热、深部淋巴结肿大、巨脾、肝肿大及严重高钙血症,酷似恶性肿瘤。在抗结核治疗失败、排除鉴别诊断并随后出现皮肤结节后,确诊为结节病。该病例凸显了认识结节病孤立性肺外假瘤样表现的重要性,此类表现可能导致诊断延迟。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/514c/12414097/f4c2c3601194/OMJ-40-02-2300352-f1.jpg

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