Miranda Ishal, Misra Biyas, Manjunath Manasa Chikballapur, Nayak Geetha, Likhitha Ullal, Nayak Usha Yogendra
Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India.
Adv Pharm Bull. 2025 May 31;15(2):284-292. doi: 10.34172/apb.025.43330. eCollection 2025 Jul.
Nanotechnology has revolutionized drug delivery, which offers innovative ways to maximize treatment efficacy while decreasing side effects. The lyotropic liquid crystalline nanoparticles (LLCNP), such as cubosomes and hexosomes, have gained substantial interest because of their distinctive molecular arrangements. Lipophilic, hydrophilic, and amphiphilic drugs can be encapsulated by cubosomes, making them versatile carriers in drug delivery systems. Different types of cubosomes, such as pH-responsive, temperature-responsive, light-responsive, enzyme-responsive, and multi-stimuli-responsive, have been discussed in this review detailing their preparation methods and therapeutic applications. Cubosomes possess high surface area, are biocompatible, and provide enhanced drug protection. However, formulation stability and scalability are the main challenges. This paper highlights the potential of cubosomes for targeted drug delivery, focusing on their ability to optimize bioavailability and controlled drug release.
纳米技术彻底改变了药物递送方式，它提供了创新方法，既能最大限度地提高治疗效果，又能减少副作用。溶致液晶纳米颗粒（LLCNP），如立方液晶纳米粒和六方液晶纳米粒，因其独特的分子排列而备受关注。亲脂性、亲水性和两亲性药物都可以被立方液晶纳米粒包裹，使其成为药物递送系统中的多功能载体。本文综述了不同类型的立方液晶纳米粒，如pH响应型、温度响应型、光响应型、酶响应型和多刺激响应型，详细介绍了它们的制备方法和治疗应用。立方液晶纳米粒具有高比表面积、生物相容性好，并能增强药物保护作用。然而，制剂稳定性和可扩展性是主要挑战。本文重点介绍了立方液晶纳米粒在靶向药物递送方面的潜力，着重阐述了它们优化生物利用度和控制药物释放的能力。
