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单一机构引入骶骨阴道固定术后七年的盆腔器官脱垂治疗结果

Treatment Outcomes of Pelvic Organ Prolapse Seven Years After the Introduction of Sacrocolpopexy at a Single Institution.

作者信息

Oi Yuka, Matsunaga Tatuya, Nakagawa Sayako, Dofutsu Mihoko, Segawa Keiko, Shimura Mai, Arata Yoshiko, Furuno Atsuko, Katayama Kayo, Chaki Osamu

机构信息

Obstetrics and Gynecology, Yokohama Rosai Hospital, Yokohama, JPN.

Obstetrics and Gynecology, Saiseikai Yokohamashi Nanbu Hospital, Yokohama, JPN.

出版信息

Cureus. 2025 Aug 8;17(8):e89647. doi: 10.7759/cureus.89647. eCollection 2025 Aug.

DOI:10.7759/cureus.89647
PMID:40922887
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12414616/
Abstract

Introduction Pelvic organ prolapse (POP) affects up to 30% of women during their lifetime and significantly impairs quality of life. In Japan, laparoscopic sacrocolpopexy was covered by national insurance starting in 2014 and has become an established treatment option. Objective This study evaluates the long-term outcomes of POP surgery, including recurrence and complications, seven years after the introduction of sacrocolpopexy at our institution. Methods Our institution introduced sacrocolpopexy in 2016, while continuing to perform conventional vaginal surgery. Sacrocolpopexy was primarily offered to patients under 80 years of age without diabetes; for other patients, vaginal surgery was generally chosen. Among vaginal surgeries, patients with a favorable general condition underwent native tissue repair (NTR). We retrospectively reviewed the medical records of patients who underwent sacrocolpopexy or NTR between April 2016 and June 2023. Results During the period, 90 patients underwent POP surgery, with 37 undergoing sacrocolpopexy and 38 receiving NTR; these 75 cases were included in the analysis. In the sacrocolpopexy group, the median time from symptom onset to surgery was 24 months, and 22 patients had used a pessary preoperatively. The median operative time for sacrocolpopexy was 196 minutes, with minimal bleeding and no intraoperative complications. Postoperative adverse events after sacrocolpopexy included one case each of delirium and acute cholecystitis. Recurrence of stage II or higher POP was observed in three patients in the sacrocolpopexy group; two of these had preoperative stage IV disease and had waited 60 months from symptom onset to surgery. In the NTR group, the median time to surgery was 42 months, and 32 patients had used a pessary preoperatively. The median operative time for NTR was 89 minutes, with minimal bleeding and no intraoperative complications. One postoperative complication (vaginal cuff hematoma) was observed after NTR. Recurrence of POP stage II or higher occurred in three NTR patients, all of whom were stage III or higher preoperatively. Conclusion Sacrocolpopexy and NTR are effective surgical options for POP, particularly in patients who do not respond to conservative management. Although sacrocolpopexy and NTR had a low complication and recurrence rate, it is important to bear in mind that recurrence is possible.

摘要

引言

盆腔器官脱垂(POP)在女性一生中的影响率高达30%,并严重损害生活质量。在日本,腹腔镜骶骨阴道固定术自2014年起纳入国家医保,已成为一种既定的治疗选择。

目的

本研究评估了在我院引入骶骨阴道固定术后七年,POP手术的长期效果,包括复发和并发症情况。

方法

我院于2016年引入骶骨阴道固定术,同时继续开展传统阴道手术。骶骨阴道固定术主要提供给80岁以下无糖尿病的患者;其他患者一般选择阴道手术。在阴道手术中,一般状况良好的患者接受自体组织修复(NTR)。我们回顾性分析了2016年4月至2023年6月期间接受骶骨阴道固定术或NTR的患者的病历。

结果

在此期间,90例患者接受了POP手术,其中37例行骶骨阴道固定术,38例接受NTR;这75例纳入分析。在骶骨阴道固定术组,从症状出现到手术的中位时间为24个月,22例患者术前使用过子宫托。骶骨阴道固定术的中位手术时间为196分钟,出血极少,无术中并发症。骶骨阴道固定术后的术后不良事件包括1例谵妄和1例急性胆囊炎。骶骨阴道固定术组有3例患者出现II期或更高分期的POP复发;其中2例术前为IV期疾病,从症状出现到手术等待了60个月。在NTR组,手术的中位时间为42个月,32例患者术前使用过子宫托。NTR的中位手术时间为89分钟,出血极少,无术中并发症。NTR术后观察到1例并发症(阴道残端血肿)。3例NTR患者出现II期或更高分期的POP复发,术前均为III期或更高分期。

结论

骶骨阴道固定术和NTR是治疗POP的有效手术选择,尤其适用于对保守治疗无反应的患者。虽然骶骨阴道固定术和NTR的并发症和复发率较低,但必须牢记复发是有可能的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f6b/12414616/d6aea59abff3/cureus-0017-00000089647-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f6b/12414616/d6aea59abff3/cureus-0017-00000089647-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f6b/12414616/d6aea59abff3/cureus-0017-00000089647-i01.jpg

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本文引用的文献

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Outcomes of robotic sacrocolpopexy.机器人骶骨阴道固定术的治疗效果。
Obstet Gynecol Sci. 2023 Nov;66(6):509-517. doi: 10.5468/ogs.23073. Epub 2023 Jul 18.
2
Effect of Pessary vs Surgery on Patient-Reported Improvement in Patients With Symptomatic Pelvic Organ Prolapse: A Randomized Clinical Trial.**标题**:子宫托与手术治疗症状性盆腔器官脱垂患者患者报告改善的效果:一项随机临床试验 **摘要**:背景:子宫托是治疗盆腔器官脱垂(POP)的一种选择,但与手术相比,其对患者报告的结局的影响尚不清楚。 **方法**:在这项多中心、随机临床试验中,我们将患有中重度 POP 和尿失禁的绝经后女性随机分配(1:1)接受子宫托或手术治疗。主要结局是在 12 个月时通过改良的盆腔器官脱垂定量问卷(POP-Q)评估的患者报告的盆腔器官脱垂和尿失禁症状的改善。次要结局包括通过国际尿失禁咨询委员会尿失禁问卷短表(ICI-Q-SF)评估的尿失禁症状的改善、POP 相关生活质量的变化、POP 对性生活的影响、不良事件以及患者满意度。 **结果**:2015 年 9 月 29 日至 2019 年 6 月 28 日期间,我们共随机分配了 453 名女性,其中 226 名被分配至子宫托组,227 名被分配至手术组。215 名女性(95.2%)完成了 12 个月的随访。在 12 个月时,子宫托组与手术组相比,POP-Q 中盆腔器官脱垂的任何部分的改善(主要结局)没有显著差异(平均差异,-0.69 点;95%置信区间 [CI],-1.38 至 0.00),但子宫托组的阴道前壁膨出(P =.02)和会阴下降(P =.04)的改善较小。两组之间的尿失禁症状的改善(主要结局)、POP 相关生活质量的变化、POP 对性生活的影响以及不良事件的发生率均无显著差异。两组患者的满意度相似(子宫托组为 77.1%,手术组为 74.6%)。 **结论**:在患有中重度 POP 和尿失禁的绝经后女性中,12 个月时,与手术相比,子宫托对患者报告的盆腔器官脱垂和尿失禁症状的改善无显著差异。 **临床试验注册**:ClinicalTrials.gov 编号:NCT02463425。
JAMA. 2022 Dec 20;328(23):2312-2323. doi: 10.1001/jama.2022.22385.
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[CLINICAL OUTCOMES OF LAPAROSCOPIC SACROCOLPOPEXY FOR PELVIC ORGAN PROLAPSE: A RETROSPECTIVE ANALYSIS OF 500 CASES FROM A SINGLE INSTITUTION].
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Robot-assisted sacrocolpopexy for pelvic organ prolapse: surgical technique and outcomes at a single high-volume institution.机器人辅助经阴道骶骨阴道固定术治疗盆腔器官脱垂:单一大容量医疗机构的手术技术和结局。
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