Gonzalez Jeffrey, Avellan Rima, Barreto Lopez Claudette, Bedran Kebir, Del Pilar Bonilla Lorena
Herbert Wertheim College of Medicine, Florida International University, Miami, USA.
Family Medicine, Baptist Health South Florida, Miami, USA.
Cureus. 2025 Aug 8;17(8):e89609. doi: 10.7759/cureus.89609. eCollection 2025 Aug.
In this report, we present the case of a 39-year-old immunocompetent female with acute meningitis/encephalitis secondary to human herpesvirus 6 (HHV-6). Her initial symptoms included fever, hallucinations, and tremors, which prompted a broad diagnostic workup for infectious and autoimmune causes of encephalopathy. Her cerebrospinal fluid (CSF) initially tested negative for viral pathogens. Subsequently, a polymerase chain reaction test confirmed the presence of HHV-6 in the CSF. The patient ultimately received antiviral therapy with ganciclovir and foscarnet, which resulted in clinical improvement. This case report highlights the importance of including HHV-6 in the diagnostic workup of encephalitis in immunocompetent individuals.
在本报告中，我们介绍了一例39岁免疫功能正常的女性，她因人类疱疹病毒6型（HHV-6）继发急性脑膜炎/脑炎。她最初的症状包括发热、幻觉和震颤，这促使对脑病的感染性和自身免疫性病因进行广泛的诊断检查。她的脑脊液（CSF）最初检测病毒病原体呈阴性。随后，聚合酶链反应检测证实脑脊液中存在HHV-6。患者最终接受了更昔洛韦和膦甲酸钠抗病毒治疗，临床症状得到改善。本病例报告强调了在免疫功能正常个体的脑炎诊断检查中纳入HHV-6的重要性。
