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人疱疹病毒6型脑炎患者的长期预后

Long-term Outcomes of Patients With Human Herpesvirus 6 Encephalitis.

作者信息

Fida Madiha, Hamdi Ahmed M, Bryson Alexandra, Razonable Raymund R, Abu Saleh Omar

机构信息

Division of Infectious Diseases, Virginia Commonwealth University Health System, Richmond, Virginia.

Department of Pathology, Virginia Commonwealth University Health System, Richmond, Virginia.

出版信息

Open Forum Infect Dis. 2019 Jun 5;6(7):ofz269. doi: 10.1093/ofid/ofz269. eCollection 2019 Jul.

DOI:10.1093/ofid/ofz269
PMID:31334297
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6634437/
Abstract

Human herpesviruses 6 (HHV-6) A and B cause encephalitis in patients with hematologic malignancies, especially those undergoing allogeneic hematopoietic stem cell transplantation. In this cohort of 10 patients, persistent neurologic deficits associated with moderate to severe bilateral hippocampal atrophy were characteristic long-term findings, despite prolonged antiviral treatment.

摘要

人类疱疹病毒6型（HHV-6）A和B可导致血液系统恶性肿瘤患者发生脑炎，尤其是那些接受异基因造血干细胞移植的患者。在这个由10名患者组成的队列中，尽管进行了长期抗病毒治疗，但与中度至重度双侧海马萎缩相关的持续性神经功能缺损是典型的长期表现。

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Long-term Outcomes of Patients With Human Herpesvirus 6 Encephalitis.人疱疹病毒6型脑炎患者的长期预后
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2
High Incidence of Early Human Herpesvirus-6 Infection in Children Undergoing Haploidentical Manipulated Stem Cell Transplantation for Hematologic Malignancies.高发生率的早期人类疱疹病毒-6 感染在接受单倍体造血干细胞移植治疗血液系统恶性肿瘤的儿童中。
Biol Blood Marrow Transplant. 2018 Dec;24(12):2549-2557. doi: 10.1016/j.bbmt.2018.07.033. Epub 2018 Jul 29.
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Human herpesvirus 6 encephalitis in patients administered mycophenolate mofetil as prophylaxis for graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.接受霉酚酸酯预防异基因造血干细胞移植后移植物抗宿主病的患者发生人疱疹病毒6型脑炎。
Transpl Infect Dis. 2019 Feb;21(1):e13024. doi: 10.1111/tid.13024. Epub 2018 Nov 27.
4
[Human Herpesvirus-6 Encephalitis in Allogeneic Hematopoietic Stem Cell Transplantation].[异基因造血干细胞移植中的人疱疹病毒6型脑炎]
Brain Nerve. 2015 Jul;67(7):919-30. doi: 10.11477/mf.1416200231.
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Long-term outcome of human herpesvirus-6 encephalitis after allogeneic stem cell transplantation.异基因干细胞移植后人类疱疹病毒 6 脑炎的长期预后。
Biol Blood Marrow Transplant. 2011 Sep;17(9):1389-94. doi: 10.1016/j.bbmt.2011.01.014. Epub 2011 Feb 4.
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Guidelines from the 2017 European Conference on Infections in Leukaemia for management of HHV-6 infection in patients with hematologic malignancies and after hematopoietic stem cell transplantation.2017 年欧洲白血病感染会议关于血液系统恶性肿瘤患者和造血干细胞移植后人类疱疹病毒 6 感染管理的指南。
Haematologica. 2019 Nov;104(11):2155-2163. doi: 10.3324/haematol.2019.223073. Epub 2019 Aug 29.
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[Human herpesvirus-6 associated with hematopoietic stem cell transplantation].与造血干细胞移植相关的人疱疹病毒6型
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Clin Infect Dis. 2013 Sep;57(5):671-81. doi: 10.1093/cid/cit358. Epub 2013 May 30.

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Less Known Gastrointestinal Manifestations of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome: A Systematic Review of the Literature.药物超敏反应伴嗜酸性粒细胞增多和全身症状（DRESS）综合征鲜为人知的胃肠道表现：文献系统综述
J Clin Med. 2021 Sep 21;10(18):4287. doi: 10.3390/jcm10184287.
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Human Herpesviruses 6A and 6B in Brain Diseases: Association versus Causation.人类疱疹病毒 6A 和 6B 与脑部疾病：关联与因果关系。
Clin Microbiol Rev. 2020 Nov 11;34(1). doi: 10.1128/CMR.00143-20. Print 2020 Dec 16.
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The Presence of Human Herpesvirus 6 in the Brain in Health and Disease.人类疱疹病毒 6 在健康和疾病中的大脑存在。
Biomolecules. 2020 Nov 6;10(11):1520. doi: 10.3390/biom10111520.

本文引用的文献

1
Clinical characteristics and outcome of human herpesvirus-6 encephalitis after allogeneic hematopoietic stem cell transplantation.异基因造血干细胞移植后人类疱疹病毒 6 脑炎的临床特征和结局。
Bone Marrow Transplant. 2017 Nov;52(11):1563-1570. doi: 10.1038/bmt.2017.175. Epub 2017 Aug 7.
2
Cord-blood hematopoietic stem cell transplant confers an increased risk for human herpesvirus-6-associated acute limbic encephalitis: a cohort analysis.脐带血造血干细胞移植可增加人类疱疹病毒 6 相关急性边缘叶脑炎的风险：队列分析。
Biol Blood Marrow Transplant. 2012 Nov;18(11):1638-48. doi: 10.1016/j.bbmt.2012.04.016. Epub 2012 May 4.
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Chromosomally integrated human herpesvirus 6: questions and answers.染色体整合型人类疱疹病毒 6：问题与解答。
Rev Med Virol. 2012 May;22(3):144-55. doi: 10.1002/rmv.715. Epub 2011 Nov 4.
4
HHV-6 reactivation and its effect on delirium and cognitive functioning in hematopoietic cell transplantation recipients.HHV-6 再激活及其对造血细胞移植受者谵妄和认知功能的影响。
Blood. 2011 May 12;117(19):5243-9. doi: 10.1182/blood-2010-10-316083. Epub 2011 Mar 9.
5
Human herpes virus 6 infection is a hallmark of cord blood transplant in adults and may participate to delayed engraftment: a comparison with matched unrelated donors as stem cell source.人类疱疹病毒 6 感染是成人脐带血移植的一个标志，可能参与延迟植入：与匹配的无关供体作为干细胞来源的比较。
Bone Marrow Transplant. 2010 Jul;45(7):1204-11. doi: 10.1038/bmt.2009.326. Epub 2009 Nov 23.
6
The management of encephalitis: clinical practice guidelines by the Infectious Diseases Society of America.《脑炎的管理：美国传染病学会临床实践指南》
Clin Infect Dis. 2008 Aug 1;47(3):303-27. doi: 10.1086/589747.
7
Plasma HHV-6 viral load-guided preemptive therapy against HHV-6 encephalopathy after allogeneic stem cell transplantation: a prospective evaluation.异基因造血干细胞移植后针对HHV-6脑病的血浆HHV-6病毒载量引导的抢先治疗：一项前瞻性评估
Bone Marrow Transplant. 2008 Feb;41(3):279-85. doi: 10.1038/sj.bmt.1705907. Epub 2007 Nov 26.
8
Post-transplant acute limbic encephalitis: clinical features and relationship to HHV6.移植后急性边缘叶脑炎：临床特征及其与HHV6的关系
Neurology. 2007 Jul 10;69(2):156-65. doi: 10.1212/01.wnl.0000265591.10200.d7.
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Risk factors for developing human herpesvirus 6 (HHV-6) reactivation after allogeneic hematopoietic stem cell transplantation and its association with central nervous system disorders.异基因造血干细胞移植后发生人类疱疹病毒6型（HHV-6）再激活的危险因素及其与中枢神经系统疾病的关联。
Biol Blood Marrow Transplant. 2007 Jan;13(1):100-6. doi: 10.1016/j.bbmt.2006.09.003.
10
Detection of active human herpesvirus-6 infection in the brain: correlation with polymerase chain reaction detection in cerebrospinal fluid.脑部活动性人类疱疹病毒6型感染的检测：与脑脊液中聚合酶链反应检测结果的相关性
J Infect Dis. 2007 Feb 1;195(3):450-4. doi: 10.1086/510757. Epub 2006 Dec 27.