AlBargawi Salma
Department of Dermatology, College of Medicine, Imam Mohammad Bin Saud University, Riyadh, Saudi Arabia.
J Cosmet Dermatol. 2025 Sep;24(9):e70442. doi: 10.1111/jocd.70442.
Necklines are a common complaint in patients as they are a sign of aging. Hyaluronic acid (HA) fillers are widely used to address volume loss and linear depressions. HA fillers are safe, effective, and versatile, but their use for necklines is not well-documented in the literature.
To report a rare case of persistent, treatment-resistant early-onset nodules in the neck follwoing HA "skin booster" filler injection. Furthermore, to highlight the importance of injector expertise as this complication often arises from technical error.
PATIENT/METHODS: A 40-year-old woman presented with nodules on the neck following HA "skinbooster" filler (Restylane Vital; Galderma; Sweden). The nodules were firm, non-tender, non-inflamed, and located in the superficial layer of the skin, suggesting that a superficial injection of the filler had been performed. She reported undergoing five separate sessions of hyaluronidase, yet no improvement was observed and the nodules persistent for 6 months afterwards.
At 1 week, significant reduction in neck nodules after 300 IU/mL of hyaluronidase was injected. The patient reported high satisfaction with the outcome.
This case highlights the importance of injector expertise and technique, especially when treating critical areas like the neck. Moreover, further research is needed to determine the optimal protocol for persistent and treatment-resistant complications such as this case.
颈部皱纹是患者常见的困扰，因为它们是衰老的迹象。透明质酸（HA）填充剂被广泛用于解决容量流失和线状凹陷问题。HA填充剂安全、有效且用途广泛，但在文献中其用于颈部皱纹的情况记录并不充分。
报告1例在注射HA“皮肤强化剂”填充剂后颈部出现持续性、难治性早发性结节的罕见病例。此外，强调注射者专业知识的重要性，因为这种并发症通常源于技术失误。
患者/方法：一名40岁女性在注射HA“皮肤强化剂”填充剂（瑞蓝唯瑅；高德美；瑞典）后颈部出现结节。这些结节质地坚硬，无压痛，无炎症，位于皮肤表层，提示填充剂注射过浅。她报告接受了5次单独的透明质酸酶治疗，但未见改善，结节在之后持续了6个月。
在第1周，注射300 IU/mL透明质酸酶后颈部结节明显减少。患者对结果表示高度满意。
该病例强调了注射者专业知识和技术的重要性，尤其是在治疗如颈部等关键部位时。此外，需要进一步研究以确定针对此类持续性和难治性并发症的最佳方案。
