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Super effect or methodological flaw: questioning the glucagon-like peptide-1 receptor agonist cancer narrative.

作者信息

Maier Gregor A, Rathmann Wolfgang, Kuß Oliver

机构信息

Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany.

German Center for Diabetes Research, Partner Düsseldorf, München-Neuherberg, Germany.

出版信息

Diabetologia. 2025 Sep 8. doi: 10.1007/s00125-025-06538-9.

DOI:10.1007/s00125-025-06538-9
PMID:40924113
Abstract
摘要

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Super effect or methodological flaw: questioning the glucagon-like peptide-1 receptor agonist cancer narrative.超级效应还是方法学缺陷：质疑胰高血糖素样肽-1受体激动剂与癌症的关系
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Super effect or methodological flaw: questioning the glucagon-like peptide-1 receptor agonist cancer narrative. Reply to Maier GA, Rathmann W, Kuß O [letter].超级效应还是方法学缺陷：质疑胰高血糖素样肽-1受体激动剂与癌症的关系。对迈尔·G·A、拉特曼·W、库斯·O [信件]的回复
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本文引用的文献

1
Glucagon-like peptide-1 receptor agonists and gastrointestinal cancer risk in individuals with type 2 diabetes.胰高血糖素样肽-1受体激动剂与2型糖尿病患者的胃肠道癌症风险
Diabetologia. 2025 Jun 5. doi: 10.1007/s00125-025-06453-z.
2
Too good to be true: Are GLP-1 receptor agonists the new metformin?好得难以置信：GLP-1 受体激动剂是新型二甲双胍？
J Diabetes Complications. 2024 Oct;38(10):108851. doi: 10.1016/j.jdiacomp.2024.108851. Epub 2024 Aug 30.
3
Glucagon-Like Peptide 1 Receptor Agonists and 13 Obesity-Associated Cancers in Patients With Type 2 Diabetes.
胰高血糖素样肽 1 受体激动剂与 2 型糖尿病患者的 13 种肥胖相关癌症。
JAMA Netw Open. 2024 Jul 1;7(7):e2421305. doi: 10.1001/jamanetworkopen.2024.21305.
4
Core concepts in pharmacoepidemiology: Confounding by indication and the role of active comparators.药物流行病学的核心概念：指示性混杂和活性对照物的作用。
Pharmacoepidemiol Drug Saf. 2022 Mar;31(3):261-269. doi: 10.1002/pds.5407. Epub 2022 Jan 27.
5
Observational studies of the association between glucose-lowering medications and cardiovascular outcomes: addressing methodological limitations.降糖药物与心血管结局关联的观察性研究：应对方法学局限性
Diabetologia. 2014 Nov;57(11):2237-50. doi: 10.1007/s00125-014-3364-z. Epub 2014 Sep 12.
6
Metformin and the risk of cancer: time-related biases in observational studies.二甲双胍与癌症风险：观察性研究中的时间相关性偏倚。
Diabetes Care. 2012 Dec;35(12):2665-73. doi: 10.2337/dc12-0788.