Ninghetto Marco, Keliris Georgios A, Szulborski Kamil, Gałecki Tomasz, Kossowski Bartosz, Panneman Daan, Cremers Frans P M, Ołdak Monika, Szaflik Jacek P, Burnat Kalina
Nencki Institute of Experimental Biology, PAS, 3 Pasteur Street, 02-093 Warsaw, Poland.
Department of Neurology, Brigham and Women's Hospital Harvard Medical School Boston, 60 Fenwood Rd 1st Floor, Boston, MA 02115, United States.
Cereb Cortex. 2025 Aug 1;35(8). doi: 10.1093/cercor/bhaf237.
In the visual cortices, receptive fields (RFs) are arranged in a gradient from small sizes in the center of the visual field to the largest sizes at the periphery. Using functional magnetic resonance imaging (fMRI) mapping of population RFs, we investigated RF adaptation in V1, V2, and V3 in patients after long-term photoreceptor degeneration affecting the central (Stargardt disease [STGD]) and peripheral (Retinitis Pigmentosa [RP]) regions of the retina. In controls, we temporarily limited the visual field to the central 10° to model peripheral loss. The central loss experienced by STGD patients led to an increase in RF size in the dorsal subdivisions of V1, V2, and V3. In contrast, peripheral loss in RP patients led to a bilateral increase in population RF sizes in V1 but a decrease in V2. Transient peripheral loss in controls led to an increase in RF size in V1 and a decrease in V2 and V3, regardless of the dorsal-ventral division of the cortical representation. Our findings suggest a dorsal-ventral difference in RF size in response to central visual field loss, likely reflecting the functional relevance of these divisions within the cortical representations of the visual field.
在视觉皮层中，感受野（RFs）呈梯度排列，从视野中心的小尺寸到周边的最大尺寸。利用群体感受野的功能磁共振成像（fMRI）图谱，我们研究了长期光感受器变性影响视网膜中央（斯塔加特病[STGD]）和周边（视网膜色素变性[RP]）区域的患者V1、V2和V3中的感受野适应情况。在对照组中，我们暂时将视野限制在中央10°以模拟周边视野丧失。STGD患者经历的中央视野丧失导致V1、V2和V3背侧亚区的感受野大小增加。相比之下，RP患者的周边视野丧失导致V1中群体感受野大小双侧增加，但V2中减小。对照组的短暂周边视野丧失导致V1中感受野大小增加，V2和V3中减小，无论皮质表征的背腹划分如何。我们的研究结果表明，在响应中央视野丧失时，感受野大小存在背腹差异，这可能反映了这些划分在视野皮质表征中的功能相关性。
