单细胞时代乳腺上皮细胞类型的定义
Defining breast epithelial cell types in the single-cell era.
作者信息
Gray G Kenneth, Carlson Eric G, Lev Tatyana, Marshall Bailey, Reed Austin D, Sánchez-Covarrubias Alex P, Twigger Alecia-Jane, Puig-Barbe Aleix, Thennavan Aatish, Omotoso Ayodele, Murrow Lyndsay M, Chatterjee Deeptiman, He Siyuan, Pensa Sara, Aevermann Brian, Tavares Norbert K, Chen Natalie, Hilton Jason A, Blake Kerrigan, Liu Yunlong, Phong Kiet, Gartner Zev J, Lawson Devon A, Swarbrick Alexander, Dos Santos Camila O, George Sophia H L, Brugge Joan S, LaBarge Mark A, Nakshatri Harikrishna, Navin Nicholas, Kessenbrock Kai, Khaled Walid T
机构信息
Department of Cell Biology, Harvard Medical School, Boston, MA, USA; Ludwig Center at Harvard, Boston, MA, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Beckman Research Institute, City of Hope, Duarte, CA, USA.
出版信息
Dev Cell. 2025 Sep 8;60(17):2218-2236. doi: 10.1016/j.devcel.2025.06.032.
Single-cell studies on breast tissue have contributed to a change in our understanding of breast epithelial diversity that has, in turn, precipitated a lack of consensus on breast cell types. The confusion surrounding this issue highlights a possible challenge for advancing breast atlas efforts. In this perspective, we present our consensus on the identities, properties, and naming conventions for breast epithelial cell types and propose goals for future atlas endeavors. Our proposals and their underlying thought processes aim to catalyze the adoption of a shared model for this tissue and to serve as guidance for other investigators facing similar challenges.
对乳腺组织的单细胞研究促使我们对乳腺上皮多样性的理解发生了变化，这反过来又导致了对乳腺细胞类型缺乏共识。围绕这个问题的困惑凸显了推进乳腺图谱研究工作可能面临的挑战。从这个角度出发，我们就乳腺上皮细胞类型的身份、特性和命名惯例提出我们的共识，并为未来的图谱研究工作提出目标。我们的提议及其背后的思考过程旨在推动采用一个针对该组织的共享模型，并为面临类似挑战的其他研究人员提供指导。
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