Cheng S J
Zhonghua Zhong Liu Za Zhi. 1985 Sep;7(5):321-3.
A new mutagen, Fusarin C has been recently isolated and identified from corn meal inoculated with Fusarium moniliforme, one of the most common fungus pollutant of corn in Linxian County, a high-risk area of esophageal cancer. Fusarin C significantly induced sister chromatid exchange (SCE), micronucleus increase, chromosome aberrations, and 6-thioguanine resistant mutants in V 79 cells in the presence of microsomal preparations. Fusarin C also induced 6-thioguanine resistant mutants in V 79 cells cocultured with primary rat liver cells. The toxic action of Fusarin C on V 79 cells was much stronger in the absence of the microsomal preparations. However, Fusarin C did not show, at the highest concentration, any significant mutagenic or chromosomal damage on V 79 cells without the addition of the metabolic activation system. The possible relationship between the consumption of corn contaminated with Fusarium moniliforme and the etiology of esophageal cancer is discussed.
一种新的诱变剂——镰刀菌素C最近已从接种串珠镰刀菌的玉米粉中分离并鉴定出来，串珠镰刀菌是食管癌高发区林县玉米最常见的真菌污染物之一。在微粒体制剂存在的情况下，镰刀菌素C能显著诱导V79细胞中的姐妹染色单体交换（SCE）、微核增加、染色体畸变以及6-硫鸟嘌呤抗性突变体。镰刀菌素C还能在与原代大鼠肝细胞共培养的V79细胞中诱导6-硫鸟嘌呤抗性突变体。在没有微粒体制剂的情况下，镰刀菌素C对V79细胞的毒性作用要强得多。然而，在不添加代谢活化系统的情况下，即使在最高浓度时，镰刀菌素C对V79细胞也未表现出任何显著的诱变或染色体损伤。本文讨论了食用被串珠镰刀菌污染的玉米与食管癌病因之间可能存在的关系。
