Cheng S J, Jiang Y Z, Li M H, Lo H Z
Carcinogenesis. 1985 Jun;6(6):903-5. doi: 10.1093/carcin/6.6.903.
Fusarin C, a fungal metabolite, was recently isolated and identified from corn meal inoculated with Fusarium moniliforme which was one of the most common fungi associated with corn in Linxian county, a high-incidence area of esophageal cancer. In the presence of S-9 mix, fusarin C significantly increased the number of revertants in Salmonella typhimurium TA 100, and induced SCE, micronuclei, chromosome aberrations and 6-TG resistant mutants in V79 cells. The toxic action of fusarin C on V79 cells was much stronger in the absence of S-9 mix. However, fusarin C did not show, at the largest concentration used, any significant mutagenic or clastogenic effect on the cells without the addition of S-9 mix. The possible relationship between the consumption of corn contaminated with F. moniliforme and the cause of esophageal cancer was discussed.
镰刀菌素C是一种真菌代谢产物，最近从接种串珠镰刀菌的玉米粉中分离并鉴定出来，串珠镰刀菌是食管癌高发地区林县与玉米相关的最常见真菌之一。在存在S-9混合物的情况下，镰刀菌素C显著增加了鼠伤寒沙门氏菌TA 100中的回复突变体数量，并在V79细胞中诱导了姐妹染色单体交换、微核、染色体畸变和6-硫鸟嘌呤抗性突变体。在没有S-9混合物的情况下，镰刀菌素C对V79细胞的毒性作用要强得多。然而，在使用的最大浓度下，不添加S-9混合物时，镰刀菌素C对细胞没有显示出任何显著的诱变或致裂作用。讨论了食用被串珠镰刀菌污染的玉米与食管癌病因之间的可能关系。
