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72例退行性颈椎脊髓病患者在颈椎前路椎体次全切除融合术后3个月、6个月和12个月时的神经学和生物力学评估

Neurological and Biomechanical Evaluation of 72 Patients with Degenerative Cervical Spondylotic Myelopathy at 3, 6, and 12 Months Following Anterior Cervical Corpectomy and Fusion.

作者信息

Tan Yuelong, Li Siwei, Hao He, Luo Xu, Chen Linlin

机构信息

Department of Orthopedics, Ansteel General Hospital, Anshan, Liaoning, China.

出版信息

Med Sci Monit. 2025 Sep 10;31:e946719. doi: 10.12659/MSM.946719.

DOI:10.12659/MSM.946719
PMID:40926386
Abstract

BACKGROUND Degenerative cervical spondylotic myelopathy (CSM) is an age-related degenerative condition of the vertebral bodies, discs, and ligaments that can cause pressure on the spinal cord and nerves. Anterior cervical corpectomy and fusion is a widely used surgical approach for treating CSM, aiming to decompress the spinal cord, restore vertebral alignment, and improve fusion rates, thus providing relief to affected patients. This study was a neurological and biomechanical evaluation of 72 patients with degenerative CSM at 3, 6, and 12 months following anterior cervical corpectomy and fusion. MATERIAL AND METHODS This retrospective study included 72 patients with a diagnosis of CSM based on modified Japanese Orthopaedic Association (mJOA) scores (10-14) and magnetic resonance imaging evidence of spinal cord compression. Neurological function and cervical biomechanics were evaluated preoperatively and at 3, 6, and 12 months postoperatively. Assessments included mJOA scores, 3-dimensional cervical range of motion (measured by Coda motion system), cervical sagittal alignment (Cobb angle, sagittal vertical axis, T1 slant angle), and neck disability index. RESULTS Postoperative assessments showed significant improvements in neurological function (mJOA scores increased by 45% at 12 months, P<0.05) and cervical range of motion (mean improvement 22% at 12 months, P<0.05). Neck disability index significantly decreased (from 44.43 to 30.17, P<0.05). Postoperative imaging confirmed positive changes in cervical sagittal alignment. CONCLUSIONS Anterior cervical corpectomy and fusion significantly improves cervical biomechanics and neurological function in patients with CSM, contributing to better clinical outcomes. Further long-term studies are needed for durability and adjacent segment degeneration.

摘要

背景

退行性颈椎脊髓病(CSM)是一种与年龄相关的椎体、椎间盘和韧带退行性疾病,可导致脊髓和神经受压。颈椎前路椎体次全切除融合术是治疗CSM广泛应用的手术方法,旨在减压脊髓、恢复椎体排列并提高融合率,从而缓解患者症状。本研究是对72例退行性CSM患者在颈椎前路椎体次全切除融合术后3个月、6个月和12个月进行的神经学和生物力学评估。

材料与方法

这项回顾性研究纳入了72例根据改良日本骨科协会(mJOA)评分(10 - 14分)和脊髓受压的磁共振成像证据诊断为CSM的患者。术前及术后3个月、6个月和12个月评估神经功能和颈椎生物力学。评估包括mJOA评分、三维颈椎活动度(采用Coda运动系统测量)、颈椎矢状面排列(Cobb角、矢状垂直轴、T1倾斜角)和颈部功能障碍指数。

结果

术后评估显示神经功能有显著改善(12个月时mJOA评分提高45%,P<0.05)以及颈椎活动度有显著改善(12个月时平均改善22%,P<0.05)。颈部功能障碍指数显著降低(从44.43降至30.17,P<0.05)。术后影像学检查证实颈椎矢状面排列有积极变化。

结论

颈椎前路椎体次全切除融合术显著改善了CSM患者的颈椎生物力学和神经功能,有助于获得更好的临床结果。对于其耐久性和相邻节段退变还需要进一步的长期研究。

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