评估质子治疗中生物学引导剂量调强放疗的技术可行性。
Evaluating the technical feasibility of biology-guided dose painting in proton therapy.
作者信息
Brighi Caterina, Parrella Giovanni, Morelli Letizia, Molinelli Silvia, Magro Giuseppe, Lillo Sara, Iannalfi Alberto, Ciocca Mario, Imparato Sara, Waddington David E J, Keall Paul, Paganelli Chiara, Orlandi Ester, Baroni Guido
机构信息
Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milan, Italy.
Image X Institute, Sydney School of Health Sciences, Faculty of Medicine & Health, The University of Sydney, Sydney, Australia.
出版信息
Phys Imaging Radiat Oncol. 2025 Aug 27;35:100832. doi: 10.1016/j.phro.2025.100832. eCollection 2025 Jul.
Biology-guided voxel-level inverse prescription mapping for dose painting (DP) using diffusion-weighted magnetic resonance imaging was evaluated for technical feasibility in proton therapy for 10 skull-base chordoma patients. Patient-specific DP prescriptions were generated from tumour cellularity and implemented in a clinical treatment planning system. Compared with uniform plans, DP achieved lower conformity (although >97 %), improved target dose metrics, reduced doses to most organs at risk, and increased tumour control probability without exceeding clinical constraints. DP proton therapy is technically feasible and may enhance treatment effectiveness.
对10例颅底脊索瘤患者进行质子治疗时，评估了利用扩散加权磁共振成像进行生物学引导的体素级逆向处方映射用于剂量勾画（DP）的技术可行性。根据肿瘤细胞密度生成患者特异性的DP处方，并在临床治疗计划系统中实施。与均匀计划相比，DP的适形性较低（尽管>97%），改善了靶区剂量指标，降低了大多数危及器官的剂量，并且在不超过临床限制的情况下提高了肿瘤控制概率。DP质子治疗在技术上是可行的，并且可能提高治疗效果。
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