Kang Zhaopeng, Zhang Lin, Jiang Tao, Zhang Guangya
Department of Psychiatry, Suzhou Guangji Hospital, The Affiliated Guangji Hospital of Soochow University, 215131 Suzhou, Jiangsu, China.
Department of Psychiatry, Wuhan Mental Health Center, 430012 Wuhan, Hubei, China.
Alpha Psychiatry. 2025 Aug 26;26(4):46060. doi: 10.31083/AP46060. eCollection 2025 Aug.
Schizophrenia (SCZ) is a common, chronic, severe mental disorder that is often accompanied by dyslipidemia and linked to decreased life expectancy. The prevalence of dyslipidemia among initial-treatment and drug-naïve (ITDN) patients with SCZ and the correlates influencing its occurrence and severity were determined in this study.
Demographic and clinical data including blood pressure, blood cell count, renal function, lipid profile, fasting glucose level, and thyroid function were collected from the 668 patients with ITDN SCZ included in this study. Psychopathology and illness severity were evaluated using the Positive and Negative Symptom Scale and the Clinical Global Impression Scale - Severity of Illness, respectively.
The prevalence of dyslipidemia was 33.53% (224/668) and the influencing factors included higher education attainment (B = 0.43, = 0.018, odds ratio [OR] = 1.54) and elevated systolic blood pressure (SBP) (B = 0.04, < 0.001, OR = 1.04), which were predictive factors. Conversely, having a spouse (B = -0.40, = 0.026, OR = 0.67), higher red blood cell counts (B = -0.77, < 0.001, OR = 0.47), and higher free tetraiodothyronine (FT) levels (B = -0.06, = 0.022, OR = 0.94) were protective factors. Specifically, elevated SBP (B = 0.01, t = 2.71, = 0.007, 95% confidence interval [CI] = 0.00-0.01) predicted dyslipidemia severity, whereas higher FT levels (B = -0.02, t = -2.45, = 0.015, 95% CI = -0.04-0.00) had a protective effect.
Our study provides valuable insights into the clinical characteristics of dyslipidemia in ITDN SCZ patients. The identified factors influencing dyslipidemia occurrence and severity could serve as potential bioindicators for its prevention and intervention in clinical settings.
精神分裂症（SCZ）是一种常见、慢性、严重的精神障碍，常伴有血脂异常，并与预期寿命缩短有关。本研究确定了初治且未用药（ITDN）的SCZ患者中血脂异常的患病率及其发生和严重程度的相关影响因素。
收集了本研究纳入的668例ITDN SCZ患者的人口统计学和临床数据，包括血压、血细胞计数、肾功能、血脂谱、空腹血糖水平和甲状腺功能。分别使用阳性和阴性症状量表及临床总体印象量表-疾病严重程度来评估精神病理学和疾病严重程度。
血脂异常的患病率为33.53%（224/668），影响因素包括较高的教育程度（B = 0.43，P = 0.018，比值比[OR] = 1.54）和收缩压（SBP）升高（B = 0.04，P < 0.001，OR = 1.04），这些是预测因素。相反，有配偶（B = -0.40，P = 0.026，OR = 0.67）、较高的红细胞计数（B = -0.77，P < 0.001，OR = 0.47）和较高的游离甲状腺素（FT）水平（B = -0.06，P = 0.022，OR = 0.94）是保护因素。具体而言，SBP升高（B = 0.01，t = 2.71，P = 0.007，95%置信区间[CI] = 0.00 - 0.01）可预测血脂异常的严重程度，而较高的FT水平（B = -0.02，t = -2.45，P = 0.015，95% CI = -0.04 - 0.00）具有保护作用。
我们的研究为ITDN SCZ患者血脂异常的临床特征提供了有价值的见解。所确定的影响血脂异常发生和严重程度的因素可作为临床环境中预防和干预血脂异常的潜在生物指标。
