da Silva Carlos Eduardo, Carvalho Pedro Henrique Silva, Capretz Gabriel Cunha Garcia, Ciriaco Yasmin de Souza, de Souza Wesley Henrique Macedo, Alves Maria Eduarda Figueiredo Severiano, Borges Breno Medeiros, Ribeiro Gustavo Machado, do Carmo Mateus Henrique, Abreu Milena Cristina Faria, Higuchi Eunice, Manzano João Pádua, Candido Patrícia, Reis Sabrina T
Faculdade Atenas - Campus Passos (FAP), Passos, Minas Gerais, Brazil.
Hospital Moriah, São Paulo, Brazil.
IJID Reg. 2025 Aug 7;16:100724. doi: 10.1016/j.ijregi.2025.100724. eCollection 2025 Sep.
Urinary tract infections (UTIs) are among the most common infections worldwide, with being the predominant pathogen, particularly, in women. The rise of antimicrobial resistance, especially due to extended-spectrum β-lactamase-producing , has significantly limited treatment options, posing a serious public health concern. Rational antibiotic use and continuous monitoring of resistance patterns are essential to address this challenge. To evaluate the antimicrobial resistance profile of uropathogens isolated from patients diagnosed with UTI.
This was an observational, longitudinal, and analytical study conducted between April 2024 and January 2025, including 1171 patients diagnosed with UTI at a private hospital in São Paulo, Brazil. Data were extracted from medical records and included demographics, comorbidities, antibiotic use, and laboratory results. Statistical analysis was performed using SPSS software, applying Student's -test and chi-square test, with <0.05 considered statistically significant.
The study population consisted of 894 women and 223 men, with a mean age of 41.9 ± 14.15 years. Gram-negative bacteria were predominant, with being the most frequently isolated pathogen. High resistance rates were observed against commonly used antibiotics, particularly β-lactams and quinolones. A significant association was found between higher body mass index and antimicrobial resistance, as well as elevated serum urea levels in resistant cases.
The findings highlight a pattern of antimicrobial resistance in intensive care unit pathogens. These results highlight the need for antimicrobial stewardship, surveillance programs, and individualized therapeutic strategies based on local resistance profiles.
尿路感染（UTIs）是全球最常见的感染之一，大肠杆菌是主要病原体，在女性中尤为如此。抗菌药物耐药性的上升，尤其是由于产超广谱β-内酰胺酶的大肠杆菌所致，已显著限制了治疗选择，这构成了严重的公共卫生问题。合理使用抗生素并持续监测耐药模式对于应对这一挑战至关重要。本研究旨在评估从诊断为UTI的患者中分离出的尿路病原体的抗菌药物耐药情况。
这是一项于2024年4月至2025年1月期间进行的观察性、纵向和分析性研究，纳入了巴西圣保罗一家私立医院的1171例诊断为UTI的患者。数据从病历中提取，包括人口统计学、合并症、抗生素使用情况和实验室检查结果。使用SPSS软件进行统计分析，采用Student's t检验和卡方检验，P<0.05被认为具有统计学意义。
研究人群包括894名女性和223名男性，平均年龄为41.9±14.15岁。革兰氏阴性菌占主导，大肠杆菌是最常分离出的病原体。观察到对常用抗生素，尤其是β-内酰胺类和喹诺酮类的耐药率很高。在较高体重指数与抗菌药物耐药性之间以及耐药病例中血清尿素水平升高之间发现了显著关联。
研究结果突出了重症监护病房病原体的抗菌药物耐药模式。这些结果强调了抗菌药物管理、监测计划以及基于当地耐药情况的个体化治疗策略的必要性。
