Milsom I, Andersch B
Eur J Clin Pharmacol. 1985;29(4):443-6. doi: 10.1007/BF00613459.
Intra-uterine pressure was recorded in a dysmenorrhoeic patient for 10 h before and after administration of a single dose of ibuprofen 400 mg. Blood samples were obtained at regular intervals during the recording for determination of the serum concentration of ibuprofen by reverse HPLC. The maximum serum concentration (37.4 micrograms Ml-1) was achieved after 1 h and the terminal half-life of ibuprofen was approximately 2 h. A marked reduction in intra-uterine pressure and the severity of pain was recorded 1.5 h following the administration of ibuprofen. Despite low or non-detectable serum concentrations of ibuprofen after 4 h, intra-uterine pressure never regained the level recorded before treatment.
在一名痛经患者中，记录了单剂量服用400毫克布洛芬前后10小时的宫内压力。在记录过程中定期采集血样，通过反相高效液相色谱法测定布洛芬的血清浓度。1小时后达到最大血清浓度（37.4微克/毫升），布洛芬的终末半衰期约为2小时。服用布洛芬1.5小时后，记录到宫内压力和疼痛严重程度显著降低。尽管4小时后布洛芬的血清浓度较低或无法检测到，但宫内压力从未恢复到治疗前记录的水平。
