Dawood M Y
Am J Med. 1984 Jul 13;77(1A):87-94. doi: 10.1016/s0002-9343(84)80025-x.
Primary dysmenorrhea and secondary dysmenorrhea induced by an intrauterine device are associated with increased production and release of endometrial prostaglandins. The condition may be treated by oral contraceptives, which reduce overall menstrual fluid volume, or by a prostaglandin synthetase inhibitor, such as ibuprofen. Unless the patient wishes to use oral contraceptives for birth control, ibuprofen (Motrin) is the drug of choice because it need only be given for two to three days each cycle, does not suppress the pituitary ovarian axis, and does not cause metabolic alterations. Clinical trials have shown ibuprofen to be highly efficacious, and more effective than indomethacin, aspirin, or propoxyphene, with no or few side effects.
原发性痛经和宫内节育器引起的继发性痛经与子宫内膜前列腺素的产生和释放增加有关。这种情况可以通过减少月经总量的口服避孕药或前列腺素合成酶抑制剂（如布洛芬）来治疗。除非患者希望使用口服避孕药进行避孕，否则布洛芬（Motrin）是首选药物，因为它每个周期只需服用两到三天，不会抑制垂体卵巢轴，也不会引起代谢改变。临床试验表明，布洛芬疗效显著，比吲哚美辛、阿司匹林或丙氧芬更有效，且副作用很少或没有。
