Zhang Wenxiu, Tong Li, Jin Baofang, Sun Dalin
Department of Traditional Chinese Medicine, Qinghai Unversity Medical College, Xining, Qinghai, China.
Andrology Department of Integrative Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, China.
Front Endocrinol (Lausanne). 2025 Aug 25;16:1653975. doi: 10.3389/fendo.2025.1653975. eCollection 2025.
With the global prevalence of diabetes mellitus (DM) steadily increasing, its impact on male reproductive health has become a growing area of concern. Diabetes-induced testicular damage involves alterations in testicular cell function, hormone levels, and the integrity of the blood-testis barrier (BTB), ultimately disrupting spermatogenesis. The key pathogenic factors include hyperglycemia, oxidative stress, chronic inflammation, mitochondrial dysfunction, and the accumulation of advanced glycation end products (AGEs).This review synthesizes the latest research on diabetes-induced testicular dysfunction and spermatogenic impairment, while also exploring potential therapeutic strategies. Current interventions are primarily focused on glycemic control, with supplementary treatments involving Chinese medicine, nanoparticles, and probiotics. Although most of the current evidence is derived from preclinical studies, these findings provide important insights that may inform future clinical research on diabetes-related male reproductive dysfunction.
随着全球糖尿病（DM）患病率稳步上升，其对男性生殖健康的影响已成为一个日益受到关注的领域。糖尿病诱导的睾丸损伤涉及睾丸细胞功能、激素水平以及血睾屏障（BTB）完整性的改变，最终破坏精子发生。关键致病因素包括高血糖、氧化应激、慢性炎症、线粒体功能障碍以及晚期糖基化终产物（AGEs）的积累。本综述综合了关于糖尿病诱导的睾丸功能障碍和生精损伤的最新研究，同时也探讨了潜在的治疗策略。目前的干预措施主要集中在血糖控制，辅助治疗包括中药、纳米颗粒和益生菌。尽管目前的大多数证据来自临床前研究，但这些发现提供了重要的见解，可能为未来关于糖尿病相关男性生殖功能障碍的临床研究提供参考。
