Dörner G, Steindel E, Kohlhoff R, Reiher H, Anders B, Verlohren H J, Hielscher K
Exp Clin Endocrinol. 1985 Dec;86(2):129-40. doi: 10.1055/s-0029-1210478.
A highly significantly decreased prevalence of insulin-dependent childhood-onset diabetes (less than 1/3 of the initial prevalence rate) could be achieved in Berlin/GDR since 1973 by improving systematically diagnostic and therapeutic measures for pregnant diabetics, particularly for non-insulin-dependent gestational diabetics. In addition, a highly significantly increased incidence rate of diagnosed, diet-treated and delivered non-insulin-dependent pregnant diabetics was found between 1979 and 1983 in Berlin/GDR, Halle and Leipzig as compared to the other districts of the GDR. Simultaneously, a highly significantly decreased prevalence rate of diabetic children (less than 1/3), who were born during this period, was found in 1983 for Berlin, Halle and Leipzig as compared to the other districts of the GDR. Finally, a highly significant inverse correlation could be demonstrated for the 15 districts of the GDR between the incidence rates of diagnosed, diet-treated and delivered non-insulin-dependent pregnant diabetics and the prevalence rates of diabetic children who were born during this period (1979-1983). In view of these findings, an interruption and even a reversal of the continued dramatic increase of idiopathic insulin-dependent diabetes mellitus appears to be possible in the developed countries by preventing maternal hyperglycaemia during pregnancy and hence hyperinsulinism in the foetuses and newborns.
自1973年以来，通过系统改善对糖尿病孕妇，尤其是非胰岛素依赖型妊娠糖尿病患者的诊断和治疗措施，在柏林/东德可实现胰岛素依赖型儿童期糖尿病的患病率大幅下降（降至初始患病率的1/3以下）。此外，与东德其他地区相比，1979年至1983年期间在柏林/东德、哈雷和莱比锡发现，经诊断、饮食治疗并分娩的非胰岛素依赖型妊娠糖尿病患者的发病率显著增加。同时，1983年与东德其他地区相比，在柏林、哈雷和莱比锡发现，在此期间出生的糖尿病儿童的患病率显著下降（降至1/3以下）。最后，对于东德的15个地区，可证明经诊断、饮食治疗并分娩的非胰岛素依赖型妊娠糖尿病患者的发病率与在此期间（1979 - 1983年）出生的糖尿病儿童的患病率之间存在高度显著的负相关。鉴于这些发现，在发达国家，通过预防孕期母亲高血糖，进而预防胎儿和新生儿高胰岛素血症，有可能中断甚至扭转特发性胰岛素依赖型糖尿病持续急剧增加的趋势。
