Tian Jun, He Yuheng, Chen Yiyi, Tang Zheng, Zhou Yongzhao
Mental Health Center, West China Hospital, Sichuan University, Chengdu, China.
Integrated Care Management Center, Outpatient Department, West China Hospital, Sichuan University, Chengdu, China.
Front Public Health. 2025 Aug 25;13:1634147. doi: 10.3389/fpubh.2025.1634147. eCollection 2025.
This study aims to analyze the temporal trends in the incidence and prevalence of anorexia nervosa (AN) in China from 1992 to 2021, focusing on age, period, and cohort effects, in order to provide evidence for the prevention and control of anxiety-related disorders.
Data on the incidence and prevalence of anorexia nervosa in China were obtained from the Global Burden of Disease Study 2021. Joinpoint regression analysis was employed to assess trends over time, while an age-period-cohort (APC) model was used to estimate the net effects of age, period, and cohort variables.
From 1992 to 2021, the incidence and prevalence of anorexia nervosa among individuals under 45 years in China showed a general upward trend. The annual percent change (APC) for incidence was 1.29%, and for prevalence was 0.31%, with both rates consistently higher in females than in males. Age effects revealed that the highest incidence and prevalence occurred between ages 10 and 25, followed by a gradual decline. Period effects demonstrated a consistent upward trend across the total population. Cohort analysis indicated an intergenerational increase in the risk of anorexia nervosa.
The incidence and prevalence of anorexia nervosa among individuals under 45 years in China have increased steadily from 1992 to 2021. This growing disease burden, with marked age and gender disparities, highlights the urgent need for targeted interventions, especially among adolescents and women.
本研究旨在分析1992年至2021年中国神经性厌食症（AN）的发病率和患病率的时间趋势，重点关注年龄、时期和队列效应，以便为焦虑相关障碍的预防和控制提供证据。
中国神经性厌食症发病率和患病率的数据来自《2021年全球疾病负担研究》。采用Joinpoint回归分析评估随时间的趋势，同时使用年龄-时期-队列（APC）模型估计年龄、时期和队列变量的净效应。
1992年至2021年，中国45岁以下人群中神经性厌食症的发病率和患病率总体呈上升趋势。发病率的年度百分比变化（APC）为1.29%，患病率为0.31%，女性的这两个率始终高于男性。年龄效应显示，发病率和患病率最高的年龄段在10岁至25岁之间，随后逐渐下降。时期效应表明，整个人口中呈持续上升趋势。队列分析表明，神经性厌食症的风险在代际间有所增加。
1992年至2021年，中国45岁以下人群中神经性厌食症的发病率和患病率稳步上升。这种不断增加的疾病负担，存在明显的年龄和性别差异，凸显了针对性干预的迫切需求，尤其是在青少年和女性中。
