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α-酰基磺酰胺合成的最新进展。

Recent advances in the synthesis of -acyl sulfonamides.

作者信息

O'Driscoll Michelle, Reddy Gangireddy Sujeevan, O'Sullivan Timothy P

机构信息

School of Chemistry, University College Cork Cork T12 YN60 Ireland

School of Pharmacy, University College Cork Cork T12 YN60 Ireland.

出版信息

RSC Adv. 2025 Sep 8;15(39):32361-32406. doi: 10.1039/d5ra05157f. eCollection 2025 Sep 5.

DOI:10.1039/d5ra05157f
PMID:40927478
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12416362/
Abstract

The -acyl sulfonamide group is widespread in pharmaceutically active compounds. This is partly due to the ability of -acyl sulfonamides to act as bioisosteric equivalents of carboxylic acids. Accordingly, methods for the efficient preparation of -acyl sulfonamides are of considerable interest to medicinal chemists. In this review, we summarise developments in the synthesis of this pharmaceutically relevant functional group across a broad range of methodologies.

摘要

酰基磺酰胺基团广泛存在于具有药物活性的化合物中。这部分归因于酰基磺酰胺能够作为羧酸的生物电子等排体。因此，高效制备酰基磺酰胺的方法引起了药物化学家的极大兴趣。在本综述中，我们总结了通过广泛的方法合成这种与药物相关的官能团的进展。

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