NUS Graduate School for Integrative Sciences & Engineering (NGS), National University of Singapore, 21 Lower Kent Ridge, Republic of Singapore 119077.
Department of Chemistry, National University of Singapore, 3 Science Drive 3, Republic of Singapore 117543.
Org Lett. 2020 Aug 21;22(16):6447-6451. doi: 10.1021/acs.orglett.0c02266. Epub 2020 Aug 11.
We report herein an atroposelective N-acylation of sulfonamides using a commercially available isothiourea catalyst, ()-HBTM, with a simple procedure. The -sulfonyl anilide products can be obtained in good to high enantiopurity, which represents a new axially chiral scaffold. The application of the product as a chiral iodine catalyst is also demonstrated for the asymmetric α-oxytosylation of propiophenone.
我们在此报告了一种使用市售的异硫脲催化剂（）-HBTM 进行的对映选择性 N-酰化磺酰胺的方法，该方法具有简单的操作步骤。 -磺酰基苯胺产物可以以良好到高的对映纯度获得，这代表了一种新的轴向手性支架。还展示了产物作为手性碘催化剂在丙酰苯酮的不对称α-氧代酯化反应中的应用。
