Meng Yaqin, Tian Jing, Xiu Li Xiu, Xu Zhou
Department of Psychiatry, The First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Department of Gastroenterology, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi, China.
Front Nutr. 2025 Aug 25;12:1655051. doi: 10.3389/fnut.2025.1655051. eCollection 2025.
Dietary patterns influence psychological health, systemic inflammation, and gut microbiota composition in colon cancer patients. This study evaluates the associations of the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) score and the Dietary Index for Gut Microbiota (DI-GM) with psychological outcomes, inflammatory markers, gut microbiota diversity (Shannon index) and composition (Firmicutes/Bacteroidetes ratio), and tumor biomarkers in colon cancer patients.
A cross-sectional study was conducted on 630 colon Cancer patients. Multivariate linear regression models adjusted for demographic, clinical, and dietary factors assessed associations of MIND and DI-GM scores with depression, anxiety (HADS), sleep quality (PSQI), quality of life (FACT-C), inflammatory markers (CRP, IL-6, fecal calprotectin), F/B ratio, and tumor biomarkers (CEA, CA19-9).
Higher MIND and DI-GM scores were significantly associated with better psychological outcomes and reduced systemic inflammation. Each one-unit increase in the MIND score was associated with lower depression ( = -1.16, 95% CI: -2.24 to -0.08) and anxiety (β = -2.48, 95% CI: -4.01 to -0.95). Similarly, DI-GM was inversely associated with depression (β = -1.36, 95% CI: -1.53 to -1.20), anxiety, and inflammatory markers. Tumor biomarkers such as CA19-9 and CEA showed significant inverse associations with both scores, especially DI-GM (CA19-9: = -3.11, 95% CI: -4.93 to -1.29; CEA: β = -0.38, 95% CI: -0.55 to -0.20). The F/B ratio partially mediated the relationship between dietary scores and psychological outcomes but not inflammatory markers.
Adherence to MIND and DI-GM dietary patterns is associated with better psychological outcomes, lower inflammation, and favorable gut microbiota in colon cancer patients. DI-GM may better capture diet-gut microbiota-inflammation links, highlighting diet as a target to improve patient well-being.
饮食模式会影响结肠癌患者的心理健康、全身炎症反应和肠道微生物群组成。本研究评估了地中海-得舒饮食延缓神经退行性变干预（MIND）评分和肠道微生物群饮食指数（DI-GM）与结肠癌患者心理结局、炎症标志物、肠道微生物群多样性（香农指数）和组成（厚壁菌门/拟杆菌门比率）以及肿瘤生物标志物之间的关联。
对630例结肠癌患者进行了一项横断面研究。针对人口统计学、临床和饮食因素进行调整的多变量线性回归模型评估了MIND和DI-GM评分与抑郁、焦虑（医院焦虑抑郁量表）、睡眠质量（匹兹堡睡眠质量指数）、生活质量（癌症患者生活质量量表）、炎症标志物（C反应蛋白、白细胞介素-6、粪便钙卫蛋白）、F/B比率和肿瘤生物标志物（癌胚抗原、糖类抗原19-9）之间的关联。
较高的MIND和DI-GM评分与更好的心理结局及全身炎症反应减轻显著相关。MIND评分每增加一个单位，抑郁程度降低（β = -1.16，95%置信区间：-2.24至-0.08），焦虑程度降低（β = -2.48，95%置信区间：-4.01至-0.95）。同样，DI-GM与抑郁（β = -1.36，95%置信区间：-1.53至-1.20）、焦虑及炎症标志物呈负相关。癌胚抗原和糖类抗原19-9等肿瘤生物标志物与这两个评分均呈显著负相关，尤其是DI-GM（糖类抗原19-9：β = -3.11，95%置信区间：-4.93至-1.29；癌胚抗原：β = -0.38，95%置信区间：-0.55至-0.20）。F/B比率部分介导了饮食评分与心理结局之间的关系，但未介导与炎症标志物之间的关系。
坚持MIND和DI-GM饮食模式与结肠癌患者更好的心理结局、更低的炎症水平及良好的肠道微生物群有关。DI-GM可能能更好地捕捉饮食-肠道微生物群-炎症之间的联系，突出饮食作为改善患者健康状况的一个靶点。
