Habib Toni, Prisco Micaela, Mouanes Peter, Lahoud Chloe, Yasin Saif, Sohail Ali, Al Moussawi Hassan
Department of Internal Medicine, Staten Island University Hospital, Northwell Health, Staten Island, USA.
CUNY School of Medicine, New York, USA.
Eur J Case Rep Intern Med. 2025 Aug 22;12(9):005662. doi: 10.12890/2025_005662. eCollection 2025.
Pancreatic signet ring cell carcinoma (PSRCC) is a rare and aggressive subtype of pancreatic cancer with a dismal prognosis. We present the case of a 50-year-old male who, within six weeks, developed a pancreatic mass with liver metastases. Endoscopic ultrasound-guided biopsy confirmed PSRCC. The presentation of this tumour with distant metastasis after a negative computed tomography (CT) of the abdomen and pelvis six weeks prior underscores the highly aggressive nature of PSRCC and the crucial need for heightened clinical suspicion, especially in cases with persistent or atypical abdominal pain. This case highlights the limitations of current diagnostic modalities and emphasises the urgent need for further research into improved early detection methods, molecular characterisation and effective treatment strategies for this rare and lethal subtype of pancreatic cancer.
Aggressive malignancy can become metastatic within six weeks of a negative CT scan.A CT scan may not detect a small pancreatic lesion <2 cm.
胰腺印戒细胞癌（PSRCC）是一种罕见且侵袭性强的胰腺癌亚型，预后很差。我们报告一例50岁男性病例，该患者在六周内出现胰腺肿块并伴有肝转移。内镜超声引导下活检确诊为PSRCC。六周前腹部和盆腔计算机断层扫描（CT）结果为阴性，而此次肿瘤却出现远处转移，这凸显了PSRCC的高度侵袭性，以及提高临床怀疑度的迫切需求，尤其是在伴有持续性或非典型腹痛的病例中。该病例突出了当前诊断方式的局限性，并强调迫切需要进一步研究改进这种罕见且致命的胰腺癌亚型的早期检测方法、分子特征及有效治疗策略。
侵袭性恶性肿瘤可在CT扫描结果为阴性的六周内发生转移。CT扫描可能无法检测到小于2厘米的小胰腺病变。
