Lee Sungjoo, Chun Min Young, Jang Hyemin, Weiner Michael, Schindler Suzanne E, Shin Daeun, Kang Heekyung, Yim Sohyun, Lee Eun Hye, Kim Kyunga, Kim Hee Jin, Na Duk L, Kim Jun Pyo, Seo Sang Won
Alzheimer's Disease Convergence Research Center, Samsung Medical Center, Seoul, South Korea.
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Alzheimers Dement. 2025 Sep;21(9):e70675. doi: 10.1002/alz.70675.
We developed and validated age-related amyloid beta (Aβ) positron emission tomography (PET) trajectories using a statistical model in cognitively unimpaired (CU) individuals.
We analyzed 849 CU Korean and 521 CU non-Hispanic White (NHW) participants after propensity score matching. Aβ PET trajectories were modeled using the generalized additive model for location, scale, and shape (GAMLSS) based on baseline data and validated with longitudinal data. Subgroup analyses examined apolipoprotein E (APOE) ε4 and sex effects.
Age-related centile curves of Aβ PET Centiloid values showed stable distributions in the lower percentiles, increasing with age in the upper percentiles. NHWs exhibited steeper Aβ accumulation trajectories, particularly among APOE ε4 carriers. Calibration with longitudinal data confirmed the reliability of this cross-sectional method.
We developed a statistical model of age-related Aβ PET trajectories using baseline data, validated with longitudinal data. NHWs exhibited steeper trajectories than Koreans, suggesting population-specific differences in Aβ accumulation.
A generalized additive model for location, scale, and shape model was applied to examine age-related amyloid beta (Aβ) trajectories with baseline data. Trajectories were validated using longitudinal data, confirming model reliability. Non-Hispanic Whites exhibited steeper trajectories than Koreans, especially in apolipoprotein E ε4 carriers. Our approach enables scalable modeling of Aβ dynamics for Alzheimer's disease prevention strategies. Findings highlight the importance of multi-ethnic research in Aβ accumulation.
我们使用统计模型在认知未受损（CU）个体中开发并验证了与年龄相关的淀粉样β蛋白（Aβ）正电子发射断层扫描（PET）轨迹。
在倾向得分匹配后，我们分析了849名韩国CU参与者和521名非西班牙裔白人（NHW）CU参与者。基于基线数据，使用位置、尺度和形状广义相加模型（GAMLSS）对Aβ PET轨迹进行建模，并用纵向数据进行验证。亚组分析检验了载脂蛋白E（APOE）ε4和性别的影响。
Aβ PET Centiloid值与年龄相关的百分位数曲线在较低百分位数处显示出稳定的分布，在较高百分位数处随年龄增加。NHW人群的Aβ积累轨迹更陡峭，尤其是在APOE ε4携带者中。纵向数据校准证实了这种横断面方法的可靠性。
我们使用基线数据开发了与年龄相关的Aβ PET轨迹统计模型，并用纵向数据进行了验证。NHW人群的轨迹比韩国人更陡峭，表示Aβ积累存在人群特异性差异。
应用位置、尺度和形状广义相加模型，利用基线数据检查与年龄相关的淀粉样β蛋白（Aβ）轨迹。使用纵向数据验证轨迹，证实了模型的可靠性。非西班牙裔白人的轨迹比韩国人更陡峭，尤其是在载脂蛋白E ε4携带者中。我们的方法能够对Aβ动力学进行可扩展建模，以制定阿尔茨海默病预防策略。研究结果突出了多民族研究在Aβ积累方面的重要性。
