Thompson R, Harmon D, Yu J
Dev Psychobiol. 1985 Nov;18(6):483-99. doi: 10.1002/dev.420180606.
Young rats with lesions to either the globus pallidus, substantia nigra, median raphe, or pontine reticular formation have previously been reported to be deficient in learning a wide variety of laboratory tasks. In the current study, weanling rats subjected to one of these lesions were rested for three weeks, then examined for acquisition and extinction of a water-motivated straight alley task, and finally tested on luminous flux discriminations of increasing difficulty. All brain-damaged groups were slower than the controls in extinguishing the alley task and only the median raphe group failed to show an impairment on the discrimination problems. These results and others suggest that the foregoing lesions produce deficits in inhibitory and attentional processes. The possibility is discussed that young rats bearing these lesions might serve as a model for the investigation of the neurobiological and cognitive disturbances underlying certain classes of mental retardation in children.
先前有报道称，患有苍白球、黑质、中缝核或脑桥网状结构损伤的幼鼠在学习各种实验室任务方面存在缺陷。在当前的研究中，对遭受这些损伤之一的断奶幼鼠进行了三周的休息，然后检查它们对水驱动直线跑道任务的习得和消退情况，最后测试它们对难度逐渐增加的光通量辨别能力。所有脑损伤组在消退跑道任务方面都比对照组慢，只有中缝核组在辨别问题上没有表现出损伤。这些结果以及其他结果表明，上述损伤会导致抑制和注意力过程出现缺陷。文中讨论了这样一种可能性，即患有这些损伤的幼鼠可能作为一种模型，用于研究某些类型儿童智力迟钝背后的神经生物学和认知障碍。
