Thompson R, Ramsay A, Yu J
Physiol Behav. 1984 Jan;32(1):107-14. doi: 10.1016/0031-9384(84)90079-9.
Recent studies suggest that lesions of the median raphe or pontine reticular formation in adult rats are associated with a nonspecific (generalized) learning impairment. The present study showed that lesions in the region of the median raphe or pontine reticular formation in 21 day old rats likewise produced a nonspecific learning impairment, as evidence by significant deficits on a visual discrimination, nonvisual incline plane discrimination, 3-cul maze, and three simple spatial problems. The finding that relatively large lateral pontomesencephalic lesions did not lead to deficient learning of any of these tasks indicates that lesion locus rather than lesion size is responsible for the production of the learning deficits observed in this study.
最近的研究表明，成年大鼠中缝正中或脑桥网状结构的损伤与非特异性（全身性）学习障碍有关。本研究表明，21日龄大鼠中缝正中或脑桥网状结构区域的损伤同样会导致非特异性学习障碍，这在视觉辨别、非视觉倾斜平面辨别、三臂迷宫和三个简单空间问题上的显著缺陷中得到了证明。相对较大的脑桥中脑外侧损伤并未导致这些任务中的任何一项学习不足，这一发现表明，损伤部位而非损伤大小是导致本研究中观察到的学习缺陷的原因。
