Inouye Keiko, White Garrison, Khan Sadia, Luba Joseph, Benharash Peyman, Thankam Finosh G
Department of Translational Research, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA, 91766-1854, USA.
Division of Cardiac Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, 90095, USA.
Mol Biol Rep. 2025 Sep 10;52(1):880. doi: 10.1007/s11033-025-11001-4.
Regenerative cardiology has emerged as a novel strategy to improve cardiac healing following ischemic injury. While stem-cell-mediated cardiac regeneration has garnered much attention as a promising strategy, its value remains debated owing to the lack of ideal stem cell source candidates. Resident/endogenous cardiac-derived stromal cells (CSCs) exhibit superior therapeutic potential due to their innate abilities to differentiate into cardiac cells, especially cardiomyocytes (CM). Emerging research has highlighted diverse endogenous CSCs phenotypes and sub-types as candidates for cardiac repair. Interestingly, CSCs promote healing through angiogenesis and regenerative paracrine signaling along with replenishing CM, and CM-like cells in the ischemic heart. Unfortunately, the clonogenic properties and translational potential of CSCs are minimally explored. This review examines the healing promise of a myriad CSCs such as c-kit + cardiac cells, Sca-1 + cells, cardiosphere-derived cells, side population cells, Bm1 + cells, cardiac atrial appendage cells, cardiac adipose cells, epicardial cells, and Isl1 + cells. Also, the review highlights the areas of improvement regarding the therapeutic applications of CSC to extrapolate into the clinical arena of cardiac management.
再生心脏病学已成为改善缺血性损伤后心脏愈合的一种新策略。虽然干细胞介导的心脏再生作为一种有前景的策略备受关注，但其价值仍存在争议，因为缺乏理想的干细胞来源候选者。驻留/内源性心脏来源的基质细胞（CSCs）由于其分化为心脏细胞，特别是心肌细胞（CM）的固有能力而表现出卓越的治疗潜力。新兴研究强调了多种内源性CSCs表型和亚型作为心脏修复的候选者。有趣的是，CSCs通过血管生成和再生旁分泌信号促进愈合，同时补充缺血心脏中的CM和CM样细胞。不幸的是，CSCs的克隆特性和转化潜力研究极少。本综述探讨了多种CSCs的愈合前景，如c-kit+心脏细胞、Sca-1+细胞、心球衍生细胞、侧群细胞、Bm1+细胞、心脏心耳细胞、心脏脂肪细胞、心外膜细胞和Isl1+细胞。此外，该综述还强调了CSC治疗应用方面有待改进的领域，以便推广到心脏管理的临床领域。
