肟预处理对大鼠沙林和梭曼吸入毒性的保护作用。

The protective effect of oxime pretreatment upon the inhalative toxicity of sarin and soman in rats.

作者信息

Schoene K, Hochrainer D, Oldiges H, Krügel M, Franzes N, Bruckert H J

出版信息

Fundam Appl Toxicol. 1985 Dec;5(6 Pt 2):S84-8. doi: 10.1016/0272-0590(85)90117-4.

Abstract

The functional set-up of a static inhalation device is described. The closed system consists of a reservoir for the circulating test gas, an inhalator for "nose-only" exposure of 10 rats, and analyzers for the test gas and CO2. It has an overall volume of 200 liters. The following LCt50 values for rats exposed to noxious vapors were determined: DFP 3629, sarin 191, and soman 211 mg X min X m-3. Pretreatment with atropine (10 mg/kg) together with the oximes Toxogonin or HJ6 (each 13 mg/kg) 10 min before the exposure raised the LCt50 of sarin by a factor of 2.5 and 14, respectively. In case of soman poisoning, only HJ6 (50 mg/kg) together with atropine was effective, which increased the LCt50 by a factor of 7.

摘要

描述了一种静态吸入装置的功能设置。该封闭系统由用于循环测试气体的储存器、用于对10只大鼠进行“仅经鼻”暴露的吸入器以及测试气体和二氧化碳分析仪组成。其总体积为200升。测定了暴露于有毒蒸气的大鼠的以下LCt50值：DFP为3629、沙林为191、梭曼为211毫克·分钟·立方米⁻³。在暴露前10分钟用阿托品（10毫克/千克）与肟类药物双复磷或HJ6（各13毫克/千克）进行预处理，沙林的LCt50分别提高了2.5倍和14倍。在梭曼中毒的情况下，只有HJ6（50毫克/千克）与阿托品有效，可使LCt50提高7倍。