Ramírez-Carmona Wilmer, Díaz-Fabregat Beatriz, Chaves-Neto Antonio Hernandes, Monteiro Douglas Roberto, Pessan Juliano Pelim, Nakamune Ana Cláudia de Melo Stevanato
Universidade Estadual Paulista - Unesp, Araçatuba School of Dentistry, Department of Preventive and Restorative Dentistry, Araçatuba, SP, Brazil.
Universidade Estadual Paulista - Unesp, Araçatuba School of Dentistry, Department of Basic Science, Araçatuba, SP, Brazil.
Braz Oral Res. 2025 Sep 8;39:e071. doi: 10.1590/1807-3107bor-2025.vol39.071. eCollection 2025.
The purpose of our review was to group the evidence and attempt to provide a consensus on the behavior of salivary flow rate in patients with Down syndrome. Observational studies evaluating salivary flow rate in children and teenagers with Down syndrome compared with non-syndrome individuals were selected. Ten sources of information were researched. The risk of bias was assessed by using the Newcastle Ottawa Scale tool . Inverse Variance was ty the SMD (95% Confidence Interval). The certainty of the evidence was determined according to the GRADE approach. Fourteen studies were evaluated. The results showed, with a very low certainty of evidence, that children and teenagers with Down syndrome present a lower salivary flow rate compared with non-syndrome controls (SMD: -1.71, 95%IC: -2.81; -0.60, p < 0.05), with significant differences in the saliva collection methods (p < 0.05) (Unstimulated saliva, SMD -5.07, 95%CI: -7.96; -2.18, p < 0.01; Stimulated saliva, SMD -0.80, 95%IC: -1.78; 0.17, p = 0.11). The behavior of the salivary flow rate is not significantly different between the age groups (p = 0.60) (up to 5 years old, SMD -1.85, 95%CI: -2.90; -0.81, p < 0.01; 2 to 18 years old, SMD -1.51, 95%CI: -2.24; -0.78, p < 0.01), and the sex (p = 0.70) (Male, SMD -1.77, 95%CI: -2.39; -1.16, p < 0.01; Female, SMD -1.53, 95%CI: -2.58; -0.48, p < 0.01). Children and teenagers with Down syndrome present a lower salivary flow rate with an unstimulated saliva collection method compared to non-syndrome.
我们此次综述的目的是汇总证据，并就唐氏综合征患者的唾液流速行为达成共识。我们选取了评估唐氏综合征儿童和青少年与非综合征个体唾液流速的观察性研究。共检索了10个信息来源。使用纽卡斯尔渥太华量表工具评估偏倚风险。采用逆方差法计算标准化均数差（SMD）（95%置信区间）。根据GRADE方法确定证据的确定性。共评估了14项研究。结果显示，证据确定性非常低，唐氏综合征儿童和青少年的唾液流速低于非综合征对照组（SMD：-1.71，95%IC：-2.81；-0.60，p<0.05），唾液采集方法存在显著差异（p<0.05）（未刺激唾液，SMD -5.07，95%CI：-7.96；-2.18，p<0.01；刺激唾液，SMD -0.80，95%IC：-1.78；0.17，p = 0.11）。唾液流速行为在各年龄组之间（p = 0.60）（5岁及以下，SMD -1.85，95%CI：-2.90；-0.81，p<0.01；2至18岁，SMD -1.51，95%CI：-2.
