Miranda Roberta Magalhães, Paula Joanna Lara Saraiva de, Santos Thiago Rezende Dos, Pinto Rafaela da Silveira, Macari Soraia
Universidade Federal de Minas Gerais - UFMG, School of Dentistry, Department of Restorative Dentistry, Belo Horizonte, MG, Brazil.
Universidade Federal de Minas Gerais - UFMG, Institute of Exact Sciences Department of Statistics, Belo Horizonte, MG, Brazil.
Braz Oral Res. 2025 Sep 8;39:e090. doi: 10.1590/1807-3107bor-2025.vol39.090. eCollection 2025.
This study aimed to determine the prevalence and provide an overview of Down syndrome and child- and mother-associated factors in Brazil from 2010 to 2020. This was a cross-sectional study including epidemiological characteristics related to live births of individuals with and without Down syndrome using the Brazilian government website. The average prevalence of Down syndrome in Brazil was approximately 30.4 children per 100,000 live births during the 10-year period, corresponding to 1 case in every 3,289.47 newborns. The occurrence of Down syndrome was increased in White children, preterm births, and low birth weight infants compared to the no-Down syndrome group; however, it was decreased in males. The prevalence of Down syndrome was low among mothers without a spouse, insufficient prenatal care, and vaginal delivery. Conversely, the prevalence was high among mothers aged 35 years and older and mothers considered White. There was no evidence of a time correlation in the prevalence among the regions of Brazil during this 10-year period. It is imperative to strengthen national monitoring of the prevalence of children with Down syndrome and provide better support to mothers and public services for this group.
本研究旨在确定2010年至2020年巴西唐氏综合征的患病率，并概述与唐氏综合征相关的儿童及母亲因素。这是一项横断面研究，利用巴西政府网站，纳入了与唐氏综合征患儿及非唐氏综合征患儿活产相关的流行病学特征。在这10年期间，巴西唐氏综合征的平均患病率约为每10万活产中有30.4名儿童，即每3289.47名新生儿中有1例。与非唐氏综合征组相比，白人儿童、早产和低体重儿中唐氏综合征的发生率有所增加；然而，男性中的发生率有所下降。在无配偶、产前护理不足和经阴道分娩的母亲中，唐氏综合征的患病率较低。相反，35岁及以上的母亲和白人母亲中患病率较高。在这10年期间，巴西各地区的患病率没有时间相关性证据。必须加强对全国唐氏综合征患儿患病率的监测，并为这一群体的母亲和公共服务提供更好的支持。
