肝移植后自我报告的生活质量、冲动性及免疫抑制药物治疗依从性：一项队列研究
SELF-REPORTED QUALITY OF LIFE, IMPULSIVITY AND NON-ADHERENCE TO IMMUNOSUPPRESSIVE MEDICATION AFTER LIVER TRANSPLANTATION: A COHORT STUDY.
作者信息
Jesus-Nunes Ana Paula, Moreira Tayne M, Morais-DE-Jesus Mychelle, Paraná Raymundo, Lins-Kusterer Liliane, Quarantini Lucas C
机构信息
Universidade Federal da Bahia, Faculdade de Medicina, Programa de Pós-graduação em Medicina e Saúde, Salvador, BA. Brasil.
Universidade Federal da Bahia, Hospital Universitário Professor Edgard Santos, Laboratório de Neuropsicofarmacologia, Serviço de Psiquiatria do Salvador, BA, Brasil.
出版信息
Arq Gastroenterol. 2025 Sep 5;62:e25012. doi: 10.1590/S0004-2803.24612025-012. eCollection 2025.
OBJECTIVE
Identify psychosocial risk factors for non-adherence to medication following liver transplantation.
METHODS
We used the Medication Level Variability Index (MLVI) for the assessment of adherence in 52 subjects selected for a pre-transplant liver procedure and monitored them for 6 months following transplantation. Patients were divided into exposed and non-exposed groups according to adherence, and each group was analyzed using psychosocial variables: demographic characteristics, quality of life, impulsivity, resilience, anxiety and depression.
RESULTS
Patients with non-adherence had lower scores in the SF-36v2 domains and in the components of physical and mental health, with significant differences in the physical functioning (P=0.03) and physical health component (P=0.03) domains. In addition, non-adherent patients showed higher levels of impulsiveness (P=0.04) and 44.2% of the non-adherent patients being men (P=0.04).
CONCLUSION
Physical functioning and summary of the physical components of quality of life, impulsivity and male gender were associated with low adherence to medication.
目的
确定肝移植后不遵医嘱服药的心理社会风险因素。
方法
我们使用药物水平变异性指数（MLVI）评估52名接受肝移植术前手术的受试者的依从性，并在移植后对他们进行了6个月的监测。根据依从性将患者分为暴露组和非暴露组，并使用心理社会变量对每组进行分析：人口统计学特征、生活质量、冲动性、恢复力、焦虑和抑郁。
结果
不遵医嘱服药的患者在SF-36v2领域以及身心健康成分中的得分较低，在身体功能（P=0.03）和身体健康成分（P=0.03）领域存在显著差异。此外，不遵医嘱服药的患者表现出较高的冲动性水平（P=0.04），且44.2%的不遵医嘱服药患者为男性（P=0.04）。
结论
身体功能、生活质量身体成分总结、冲动性和男性性别与服药依从性低有关。
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