Wilczek Z M
Am J Ophthalmol. 1977 Sep;84(3):299-304. doi: 10.1016/0002-9394(77)90668-7.
Radioactive carbon (14C)-labeled dacarbazine was used to trace penetration of the drug to the eye after intravenous and subtenon-retrobulbar injection on experimental animals. After subtenonretrobulbar injection of 1 or 2.5 mg of commercial dacarbazine twice daily for two weeks, there were no clinical changes. However, doses of 5 to 7.5 mg per injection produced destructive chorioretinitis, and a proliferative type of retinopathy was confirmed histopathologically.
放射性碳（14C）标记的达卡巴嗪用于追踪实验动物静脉注射和球后Tenon囊下注射后药物在眼内的渗透情况。在球后Tenon囊下每天注射1或2.5毫克市售达卡巴嗪，持续两周后，未出现临床变化。然而，每次注射5至7.5毫克的剂量会导致破坏性脉络膜视网膜炎，并且经组织病理学证实存在增殖性视网膜病变。
