Kubota Miki, Kinoshita Yuya, Hirokawa Sayaka, Shikichi Daiki, Izumi Noa, Hagiwara Naoko, Sakai Daiki, Matsuzaki Yuto, Yamamoto Minami, Takai Leo, Kon Yukito, Aoshima Yuto, Ota Raito, Kosaka Mitsuki, Sun Meiling, Kawano Yukio, Li Kou
Department of Electrical, Electronic, and Communication Engineering, Faculty of Science and Engineering, Chuo University, 1-13-27 Kasuga, Bunkyo-ku, Tokyo, 112-8551, Japan.
Laboratory for Future Interdisciplinary Research of Science and Technology, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo, 152-8552, Japan.
Light Sci Appl. 2025 Sep 11;14(1):306. doi: 10.1038/s41377-025-01957-0.
While non-destructive in-line monitoring at manufacturing sites is essential for safe distribution cycles of pharmaceuticals, efforts are still insufficient to develop analytical systems for detailed dynamic visualisation of foreign substances and material composition in target pills. Although spectroscopies, expected towards pharma testing, have faced technical challenges in in-line setups for bulky equipment housing, this work demonstrates compact dynamic photo-monitoring systems by selectively extracting informative irradiation-wavelengths from comprehensive optical references of target pills. This work develops a non-destructive in-line dynamic inspection system for pharma agent pills with carbon nanotube (CNT) photo-thermoelectric imagers and the associated ultrabroadband sub-terahertz (THz)-infrared (IR) multi-wavelength monitoring. The CNT imager in the proposed system functions in ultrabroadband regions over existing sensors, facilitating multi-wavelength photo-monitoring against external sub-THz-IR-irradiation. Under recent advances in the investigation of functional optical materials (e.g., gallium arsenide, vanadium oxide, graphene, polymers, transition metal dichalcogenides), CNTs play advantageous leading roles in collectively satisfying informative efficient photo-absorption and solution-processable configurations for printable device fabrication into freely attachable thin-film imagers in pharma monitoring sites. The above non-destructive dynamic monitoring system maintains in-line experimental setups by integrating the functional thin-film imager sheets and compact multiple photo-sources. Furthermore, permeable sub-THz-IR-irradiation, which provides different transmittance values specific to non-metallic materials per wavelength or composition, identifies constituent materials for pharma agents themselves and concealed foreign substances in a non-contact manner. This work finally inspects invisible detailed features of pharma pills with the non-destructive in-line dynamic photo-monitoring system by incorporating performances of CNT imagers and compact optical setups.
虽然在生产现场进行非破坏性在线监测对于药品的安全配送周期至关重要，但在开发用于详细动态可视化目标药丸中异物和材料成分的分析系统方面，仍存在不足。尽管有望用于药物测试的光谱技术在用于大型设备外壳的在线设置中面临技术挑战，但这项工作通过从目标药丸的综合光学参考中选择性提取信息丰富的照射波长，展示了紧凑的动态光监测系统。这项工作利用碳纳米管（CNT）光热电成像仪以及相关的超宽带亚太赫兹（THz）-红外（IR）多波长监测技术，开发了一种用于药剂药丸的非破坏性在线动态检测系统。所提出系统中的CNT成像仪在现有传感器的超宽带区域发挥作用，便于针对外部亚THz-IR照射进行多波长光监测。在功能光学材料（如砷化镓、氧化钒、石墨烯、聚合物、过渡金属二硫属化物）研究的最新进展中，碳纳米管在集体满足信息高效光吸收和可溶液处理配置以制造可打印设备成为制药监测场所中可自由附着的薄膜成像仪方面发挥了有利的主导作用。上述非破坏性动态监测系统通过集成功能薄膜成像仪片材和紧凑的多个光源来维持在线实验设置。此外，可渗透的亚THz-IR照射针对每种波长或成分提供特定于非金属材料的不同透射率值，以非接触方式识别药剂本身的组成材料和隐藏的异物。这项工作最终通过结合CNT成像仪的性能和紧凑的光学设置，利用非破坏性在线动态光监测系统检查药丸的不可见详细特征。
