Geyikoglu M Dilruba, Koc Polat Hilal, Cavusoglu Bulent, Ertugrul Mehmet
Department of Electrical and Electronics Engineering, Ataturk University, Erzurum, Turkey.
Department of Electrical and Electronics Engineering, Erzurum Technical University, Erzurum, Turkey.
Electromagn Biol Med. 2025 May 6:1-15. doi: 10.1080/15368378.2025.2500982.
Terahertz (THz) waves can overcome the side effects of traditional cancer treatment methods with their high absorption by water molecules and provide a new opportunity for the development of cancer treatment. In this study, the effect of a THz ablation system operating at 1.65 THz, recommended for use in cancer treatment, in the treatment of various cancers has been investigated. The proposed system includes three components to ensure high treatment achievement drive and electromagnetic compatibility. The first is a high-performance antenna that will generate radiation at 1.65 THz; the second is a rectangular waveguide that will direct the antenna radiation without loss; and the third is a compact pyramid-structure beam focusing apparatus that will increase focus. In silico studies were carried out for the treatment effects of the proposed system on breast, colon, and skin cancers. For terahertz ablation, treatment effects were examined using voxel data from eight people. Achievement drive parameters such as electric field, magnetic field, specific absorption rate, temperature, and tissue damage rate on healthy and diseased tissues were examined in detail. Our findings show that treatment temperature values have been reached with the THz ablation system depending on the exposure time and cancerous tissue location, and it has been determined that a high rate of tissue damage occurred. No unwanted secondary hotspots have been encountered during the treatment. Consequently, the therapeutic potential of the proposed THz wave ablation system on different cancers encourages further studies to determine the sensitivity and specificity of the system.
太赫兹（THz）波因其对水分子的高吸收率，可克服传统癌症治疗方法的副作用，为癌症治疗的发展提供了新机遇。在本研究中，已对推荐用于癌症治疗的、工作在1.65太赫兹的太赫兹消融系统在各种癌症治疗中的效果进行了研究。所提出的系统包括三个组件，以确保高治疗成效驱动和电磁兼容性。第一个是将产生1.65太赫兹辐射的高性能天线；第二个是将无损耗地引导天线辐射的矩形波导；第三个是将增强聚焦的紧凑型金字塔结构光束聚焦装置。针对所提出的系统对乳腺癌、结肠癌和皮肤癌的治疗效果进行了计算机模拟研究。对于太赫兹消融，使用来自八个人的体素数据检查了治疗效果。详细检查了健康组织和患病组织上的电场、磁场、比吸收率、温度和组织损伤率等成效驱动参数。我们的研究结果表明，太赫兹消融系统根据暴露时间和癌组织位置达到了治疗温度值，并且已确定发生了高比率的组织损伤。治疗期间未遇到不需要的二次热点。因此，所提出的太赫兹波消融系统对不同癌症的治疗潜力鼓励进一步研究以确定该系统的敏感性和特异性。
