Zheng Yin, Chen Jiabo, Su Cheng
The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, China.
Maternity and Child Health Care of Guangxi Zhuang Autonomous Region, Nanning, 530002, China.
J Cancer Res Clin Oncol. 2025 Sep 11;151(9):254. doi: 10.1007/s00432-025-06305-8.
PATZ1 (POZ/BTB and AT hook containing zinc finger 1) is an important member of the POZ/BTB (Poxvirus and Zinc finger / Broad-complex, Tramtrack, and Bric-à-brac) family and has been confirmed to be involved in the development and progression of various tumors. Moreover, differential expression of PATZ1 is associated with the prognosis of multiple cancers and systemic metabolic patterns. It participates in the regulation of oncogenes and a range of biological processes, including glucose and lipid metabolism. This review aims to summarize the current understanding of the relationship between the transcription factor PATZ1, tumorigenesis, and metabolism, with the goal of providing a theoretical basis for the development of PATZ1-targeted therapies.
PATZ1（含POZ/BTB和AT钩结构域的锌指蛋白1）是POZ/BTB（痘病毒和锌指蛋白/广泛复合体、Tramtrack和Bric-à-brac）家族的重要成员，已被证实参与多种肿瘤的发生发展。此外，PATZ1的差异表达与多种癌症的预后及全身代谢模式相关。它参与癌基因的调控以及一系列生物学过程，包括葡萄糖和脂质代谢。本综述旨在总结目前对转录因子PATZ1、肿瘤发生与代谢之间关系的认识，以期为开发以PATZ1为靶点的治疗方法提供理论依据。
