Unni Ashwin, Gaikwad Sanjay N, Gosavi Rakhi A, Pawar Lakshita
Pulmonology, Byramjee Jeejeebhoy Government Medical College, Pune, IND.
Pulmonary Medicine, Byramjee Jeejeebhoy Government Medical College, Pune, IND.
Cureus. 2025 Aug 10;17(8):e89742. doi: 10.7759/cureus.89742. eCollection 2025 Aug.
This case report highlights the case of an extremely rare case of primary pleural melanoma in a 15-year-old female with left-sided exudative pleural effusion with pleural fluid adenosine deaminase (ADA) in the tuberculosis range. Melanoma is an aggressive malignant tumor mainly arising from the skin, but very few cases have been reported of a primary melanoma arising from the pleura. In addition, this patient's pleural fluid ADA was in the tuberculosis suspect range, but a detailed analysis of the pleural fluid and pleural biopsy helped in pinpointing the diagnosis. Through this case, the entire pleural fluid analysis, including the pleural fluid routine microscopy, pleural fluid cytology, and even pleural biopsy in select cases, needs to be assessed in order to avoid misdiagnosis of tuberculosis.
本病例报告重点介绍了一名15岁女性原发性胸膜黑色素瘤的极其罕见病例，该患者左侧出现渗出性胸腔积液，胸腔积液腺苷脱氨酶（ADA）处于结核范围内。黑色素瘤是一种主要起源于皮肤的侵袭性恶性肿瘤，但原发性起源于胸膜的黑色素瘤病例报道极少。此外，该患者的胸腔积液ADA处于结核疑似范围内，但对胸腔积液和胸膜活检的详细分析有助于明确诊断。通过该病例可知，为避免误诊为结核病，需要对整个胸腔积液分析进行评估，包括胸腔积液常规显微镜检查、胸腔积液细胞学检查，甚至在某些病例中进行胸膜活检。
