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围手术期神经认知障碍:术语、临床意义及未来研究方向的全面综述

Perioperative neurocognitive disorders: a comprehensive review of terminology, clinical implications, and future research directions.

作者信息

Ren Xuli, Huiqiao Lian, Wu Yuntu, Zhang Te, Chen Peng, Li Longyun, Zhao Guoqing, Wang Fang

机构信息

Jilin University, Changchun, China.

Department of Anesthesiology, The Third Hospital of Jilin University, Changchun, Jilin, China.

出版信息

Front Neurol. 2025 Aug 26;16:1526021. doi: 10.3389/fneur.2025.1526021. eCollection 2025.

DOI:10.3389/fneur.2025.1526021
PMID:40933055
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12418783/
Abstract

Perioperative neurocognitive disorders (PNDs) encompass a spectrum of cognitive impairments that may affect patients before, during, or after surgical procedures, with significant implications for patient outcomes, and healthcare expenditures. This comprehensive review examines the evolution of PND terminology, clinical manifestations, diagnostic criteria, incidence rates, risk factors, underlying mechanisms, preventive measures, management strategies, and future research directions. The authors emphasize the importance of early diagnosis and intervention to enhance postoperative recovery and underscore the necessity of a multidisciplinary approach to patient care.

摘要

围手术期神经认知障碍(PNDs)涵盖一系列认知障碍,这些障碍可能在手术前、手术期间或手术后影响患者,对患者的预后和医疗费用有重大影响。这篇综述全面审视了PND的术语演变、临床表现、诊断标准、发病率、危险因素、潜在机制、预防措施、管理策略以及未来的研究方向。作者强调早期诊断和干预对促进术后恢复的重要性,并强调采用多学科方法进行患者护理的必要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a972/12418783/9e3ad5f4e2b3/fneur-16-1526021-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a972/12418783/9e3ad5f4e2b3/fneur-16-1526021-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a972/12418783/9e3ad5f4e2b3/fneur-16-1526021-g0001.jpg

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本文引用的文献

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Effects of transcutaneous auricular vagus nerve stimulation on postoperative delirium in older patients with hip fracture: protocol for a randomised controlled trial.经皮耳迷走神经刺激对老年髋部骨折患者术后谵妄的影响:一项随机对照试验方案
BMJ Open. 2025 Feb 20;15(2):e092413. doi: 10.1136/bmjopen-2024-092413.
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Efficacy of repetitive transcranial magnetic stimulation in preventing postoperative delirium in elderly patients undergoing major abdominal surgery: A randomized controlled trial.重复经颅磁刺激预防老年腹部大手术患者术后谵妄的疗效:一项随机对照试验。
Brain Stimul. 2025 Jan-Feb;18(1):52-60. doi: 10.1016/j.brs.2024.12.1475. Epub 2024 Dec 26.
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The utility of the Montreal cognitive assessment (MoCA) in detecting cognitive impairment in surgical populations - A systematic review and meta-analysis.
蒙特利尔认知评估(MoCA)在检测手术人群认知障碍中的效用:系统评价和荟萃分析。
J Clin Anesth. 2024 Oct;97:111551. doi: 10.1016/j.jclinane.2024.111551. Epub 2024 Jul 20.
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Postoperative Delirium and the Older Adult: Untangling the Confusion.术后谵妄与老年患者:厘清混淆。
J Neurosurg Anesthesiol. 2024 Jul 1;36(3):184-189. doi: 10.1097/ANA.0000000000000971. Epub 2024 Apr 29.
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Cognitive Training for Reduction of Delirium in Patients Undergoing Cardiac Surgery: A Randomized Clinical Trial.心脏手术患者认知训练以减少谵妄:一项随机临床试验。
JAMA Netw Open. 2024 Apr 1;7(4):e247361. doi: 10.1001/jamanetworkopen.2024.7361.
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Structural disconnectivity in postoperative delirium: A perioperative two-center cohort study in older patients.术后谵妄的结构连接中断:一项针对老年患者的围手术期两中心队列研究。
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