Bhardwaj Nitin, Chandra Harish, Singh Ashutosh, Babu Ram
Department of Zoology and Environmental Sciences, Gurukula Kangri (Deemed to be University), Haridwar 249404, India.
Department of Botany and Microbiology, Gurukula Kangri (Deemed to be University), Haridwar 249404, India.
World J Biol Chem. 2025 Sep 5;16(3):108045. doi: 10.4331/wjbc.v16.i3.108045.
Cellular communication is required for the normal function and maintenance of homeostasis. The extracellular communications are mediated by cell surface receptors, which transmit signals for various cell functions. Cell defense also relies on distinguishing between self and non-self. The integrins belong to the transmembrane receptors family and serve a crucial function in cell-extracellular adhesion and cell-cell signaling. The cell surface integrin-associated protein, or CD47, is an important integrin regulator and performs an array of functions. The CD47 interacts with the signal regulatory protein α (SIRPα) and regulates adhesion, apoptosis, phagocytosis, proliferation, metabolism, activation, hematopoietic stem cell migration, and malignancies. The CD47 expression is increased in tumor cells to escape immune response. The anti-CD47 antibodies have shown promising therapeutic strategies in various clinical trials in the treatment of hematologic and solid tumors. In the current review, we discussed multifunctional roles, molecular mechanisms, and therapeutic strategies of tumors by utilizing CD47/SIRPα interactions.
细胞通讯对于内环境稳态的正常功能和维持至关重要。细胞外通讯由细胞表面受体介导，这些受体传递各种细胞功能的信号。细胞防御也依赖于区分自身和非自身。整合素属于跨膜受体家族，在细胞与细胞外基质的黏附以及细胞间信号传导中发挥关键作用。细胞表面整合素相关蛋白，即CD47，是一种重要的整合素调节剂，具有一系列功能。CD47与信号调节蛋白α（SIRPα）相互作用，调节黏附、凋亡、吞噬作用、增殖、代谢、激活、造血干细胞迁移和恶性肿瘤。肿瘤细胞中CD47表达增加以逃避免疫反应。抗CD47抗体在治疗血液系统和实体瘤的各种临床试验中显示出有前景的治疗策略。在本综述中，我们讨论了利用CD47/SIRPα相互作用在肿瘤中的多功能作用、分子机制和治疗策略。
