Eltayeb M M, Waggiallah H A, Hakami N Y, Elmosaad Y M
Department of Nursing, Department of Medical Laboratory Science, College of Applied Medical Science, Prince Sattam Bin Abdulaziz University, Alkharj, Saudi Arabia.
Eur Rev Med Pharmacol Sci. 2023 Jan;27(2):476-482. doi: 10.26355/eurrev_202301_31047.
The purpose of this research is to discover a link between cigarette smoking and decreased red cell CD47 expression.
The current cross-sectional study included 72 smokers (who had smoked 20 cigarettes per day for at least two years) and 50 nonsmokers, as well as nonsmokers who had not been exposed to smokers on a regular basis and chose to participate as controls. Due to exclusion criteria, 11 participants were removed from the study; they had various genetic, immune, and metabolic disorders, leaving only 61 healthy people in the study. A flow cytometer was used to examine CD47.
There was a strong correlation between smoking and a decrease in CD47 markers in all types of smokers in the control samples (p-value = 0.000), as well as among cigarette smokers only (p-value = 0.000), cigarette and Shisha smokers (p-value = 0.024), and cigarette and e-cigarette smokers (p-value = 0.014). Furthermore, there is a strong correlation between the appearance of the CD47 marker in healthy smokers and smokers with non-hereditary blood diseases like iron deficiency anemia and polycythemia.
It can be concluded that smoking significantly reduces the expression of the CD47 marker.
本研究的目的是发现吸烟与红细胞CD47表达降低之间的联系。
当前的横断面研究纳入了72名吸烟者（每天吸烟20支，至少持续两年）和50名不吸烟者，以及未经常接触吸烟者且选择作为对照参与研究的不吸烟者。由于排除标准，11名参与者被排除在研究之外；他们患有各种遗传、免疫和代谢紊乱疾病，研究中仅剩下61名健康人。使用流式细胞仪检测CD47。
在对照样本中，所有类型吸烟者的吸烟与CD47标志物降低之间存在强相关性（p值 = 0.000），仅吸烟者（p值 = 0.000）、香烟和水烟吸烟者（p值 = 0.024）以及香烟和电子烟吸烟者（p值 = 0.014）之间也存在强相关性。此外，健康吸烟者以及患有缺铁性贫血和红细胞增多症等非遗传性血液疾病的吸烟者中CD47标志物的出现之间存在强相关性。
可以得出结论，吸烟会显著降低CD47标志物的表达。
