Lin Li, Zhang Ruzhi
Department of Dermatology, The Second Affiliated Hospital of Wannan Medical College, Wuhu, People's Republic of China.
Clin Cosmet Investig Dermatol. 2025 Sep 4;18:2167-2172. doi: 10.2147/CCID.S535689. eCollection 2025.
Severe varicella is relatively rare in adults and may lead to death. Our case report describes a 36-year-old man with generalized papules and vesicles. The diagnosis was severe varicella, tinea cruris and type 2 diabetes. Generalized rash of severe varicella is very rare in clinically. In this patient, three days after the appearance of the rash, the CD4+T/CD8+T ratio increased, as did the serum levels of IFN-γ, TNF-α, and IL-17A, suggesting that the balance of the immune system was disturbed and there was an increased likelihood of viral infection, which may be related to the generalized spread of the lesions. The patient was discharged from the hospital after 2 weeks of antiviral treatment along with hepatoprotective, hypoglycemic and antifungal treatment of the buttocks with the lesions significantly reduced.
严重水痘在成年人中相对罕见，且可能导致死亡。我们的病例报告描述了一名36岁的男性，他身上出现了全身性丘疹和水疱。诊断结果为严重水痘、股癣和2型糖尿病。临床上，严重水痘的全身性皮疹非常罕见。在该患者中，皮疹出现三天后，CD4+T/CD8+T比值升高，血清干扰素-γ、肿瘤坏死因子-α和白细胞介素-17A水平也升高，这表明免疫系统平衡受到干扰，病毒感染的可能性增加，这可能与皮损的全身性扩散有关。经过2周的抗病毒治疗，同时对臀部进行保肝、降糖和抗真菌治疗，皮损明显减轻后，患者出院。
