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心包内孤立性纤维瘤的定位:一例报告

Intrapericardial localization of solitary fibrous tumour: a case report.

作者信息

Alanís-Naranjo José Martín, Gil-Guzmán Omar Alejandro, Velasco-Ortiz Daniel, Pérez Montiel-Gómez Ma Delia

机构信息

Cardiovascular Imaging Department, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano 1, Mexico City 14080, Mexico.

Cardiology Department, Hospital Regional 1° de Octubre, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado (ISSSTE), Instituto Politécnico Nacional 1669, Mexico City 07760, Mexico.

出版信息

Eur Heart J Case Rep. 2025 Aug 26;9(9):ytaf422. doi: 10.1093/ehjcr/ytaf422. eCollection 2025 Sep.

Abstract

BACKGROUND

A solitary fibrous tumour (SFT) is a rare fibroblastic tumour, with primary cardiac SFT extremely rare. We report a rare case of a patient presenting with sudden dyspnoea who was diagnosed with a primary cardiac SFT.

CASE SUMMARY

A 56-year-old woman with a history of diabetes and active smoking presented with sudden dyspnoea. Computed tomography scan revealed a mass adjacent to the left ventricle. In addition to the large pericardial effusion, no signs of cardiac tamponade or valvulopathies were found on echocardiography. The patient underwent open-heart surgery and mass removal, finding a tumour located inside the pericardial sac and attached to the left ventricle's lateral wall; it did not invade other heart structures. Histological and immunohistochemical examination of the mass revealed SFT diagnosis. The patient was discharged from the hospital in full health, and follow-up examinations revealed no evidence of tumour recurrence.

DISCUSSION

Solitary fibrous tumour most commonly occurs in middle-aged patients and is not gender specific. Multimodal imaging is crucial for diagnosing and managing SFT. A definitive diagnosis must be based on both immunohistochemical and histopathological findings. STAT6 immunoexpression is the most reliable marker for histopathology diagnosis. Given the high SFT recurrence rate, follow-up is essential.

摘要

背景

孤立性纤维瘤(SFT)是一种罕见的成纤维细胞肿瘤,原发性心脏SFT极为罕见。我们报告一例罕见病例,一名患者因突发呼吸困难就诊,被诊断为原发性心脏SFT。

病例摘要

一名56岁女性,有糖尿病史且吸烟,因突发呼吸困难就诊。计算机断层扫描显示左心室旁有一肿块。超声心动图检查除发现大量心包积液外,未发现心脏压塞或瓣膜病变迹象。患者接受了心脏直视手术并切除肿块,发现肿瘤位于心包腔内并附着于左心室侧壁;未侵犯其他心脏结构。对肿块进行组织学和免疫组化检查确诊为SFT。患者康复出院,随访检查未发现肿瘤复发迹象。

讨论

孤立性纤维瘤最常见于中年患者,无性别差异。多模态成像对于SFT的诊断和管理至关重要。明确诊断必须基于免疫组化和组织病理学结果。STAT6免疫表达是组织病理学诊断最可靠的标志物。鉴于SFT复发率高,随访至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46b8/12418934/aaa8543117dd/ytaf422f1.jpg

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