Yang Lan, Gao Han, Liu Dacheng
College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, China.
Front Vet Sci. 2025 Aug 26;12:1618260. doi: 10.3389/fvets.2025.1618260. eCollection 2025.
Inflammatory bowel disease (IBD), comprising Crohn's disease (CD) and ulcerative colitis (UC), is a chronic, relapsing inflammatory disorder of the gastrointestinal tract with multifactorial etiology. The etiology and pathogenesis of ulcerative colitis are diverse, so it is crucial to explore the pathogenesis through animal models. Selecting appropriate animal models is critical for advancing our understanding of UC pathogenesis and therapeutic strategies. This review discusses various UC animal models and compares their characteristics in relation to disease mechanisms and therapeutic research.
炎症性肠病（IBD）包括克罗恩病（CD）和溃疡性结肠炎（UC），是一种病因多因素的慢性复发性胃肠道炎症性疾病。溃疡性结肠炎的病因和发病机制多种多样，因此通过动物模型探索其发病机制至关重要。选择合适的动物模型对于增进我们对UC发病机制和治疗策略的理解至关重要。本文综述讨论了各种UC动物模型，并比较了它们在疾病机制和治疗研究方面的特点。
