Yang Chunhua, Merlin Didier
Institute for Biomedical Sciences, Digestive Disease Research Group, Georgia State University, Atlanta, GA, 30303, USA.
Atlanta Veterans Affairs Medical Center, Decatur, GA, 30033, USA.
Inflamm Bowel Dis. 2024 May 2;30(5):844-853. doi: 10.1093/ibd/izad312.
Animal models of inflammatory bowel disease (IBD) are valuable tools for investigating the factors involved in IBD pathogenesis and evaluating new therapeutic options. The dextran sodium sulfate (DSS)-induced model of colitis is arguably the most widely used animal model for studying the pathogenesis of and potential treatments for ulcerative colitis (UC), which is a primary form of IBD. This model offers several advantages as a research tool: it is highly reproducible, relatively easy to generate and maintain, and mimics many critical features of human IBD. Recently, it has also been used to study the role of gut microbiota in the development and progression of IBD and to investigate the effects of other factors, such as diet and genetics, on colitis severity. However, although DSS-induced colitis is the most popular and flexible model for preclinical IBD research, it is not an exact replica of human colitis, and some results obtained from this model cannot be directly applied to humans. This review aims to comprehensively discuss different factors that may be involved in the pathogenesis of DSS-induced colitis and the issues that should be considered when using this model for translational purposes.
炎症性肠病（IBD）动物模型是研究IBD发病机制相关因素以及评估新治疗方案的宝贵工具。葡聚糖硫酸钠（DSS）诱导的结肠炎模型可以说是研究溃疡性结肠炎（UC，IBD的一种主要形式）发病机制和潜在治疗方法时使用最广泛的动物模型。作为一种研究工具，该模型具有多个优点：它具有高度可重复性，相对易于建立和维持，并且能模拟人类IBD的许多关键特征。最近，它还被用于研究肠道微生物群在IBD发生发展中的作用，以及研究饮食和遗传等其他因素对结肠炎严重程度的影响。然而，尽管DSS诱导的结肠炎是临床前IBD研究中最受欢迎且灵活的模型，但它并非人类结肠炎的精确复制品，从该模型获得的一些结果不能直接应用于人类。本综述旨在全面讨论可能参与DSS诱导结肠炎发病机制的不同因素，以及将该模型用于转化研究时应考虑的问题。
