一名70岁患者在接受胶原酶治疗佩罗尼氏病后出现迟发性阴茎骨折。
Late-Onset Penile Fracture After Collagenase Treatment for Peyronie's Disease in a 70-Year-Old Patient.
作者信息
Wainstein Matthew D, Masih Sonia E, Schuster Timothy G
机构信息
Department of Urology, The University of Toledo College of Medicine and Health Sciences, Toledo, Ohio, USA.
Genitourinary Surgeons, Promedica Toledo Hospital, Toledo, Ohio, USA.
出版信息
Case Rep Urol. 2025 Sep 2;2025:2126627. doi: 10.1155/criu/2126627. eCollection 2025.
Abstract
Collagenase (CCH) injections are the gold standard for nonsurgical management of Peyronie's disease. While generally well tolerated, penis fracture is a known complication. Cases typically occur during intercourse in the weeks following treatment. Because of this, patients are advised to abstain from sexual activity for 4 weeks postinjection. Here, we present a case of corporal rupture occurring 32 days after treatment. This is only the third reported case occurring 30 days after injection. While the risk of penis fracture likely decreases with time, these cases illustrate that the risk may extend beyond 4 weeks.
摘要
胶原酶（CCH）注射是佩罗尼氏病非手术治疗的金标准。虽然通常耐受性良好，但阴茎骨折是一种已知的并发症。病例通常发生在治疗后几周的性交过程中。因此，建议患者在注射后4周内避免性行为。在此，我们报告一例治疗后32天发生的阴茎海绵体破裂病例。这是仅有的第三例注射后30天发生的报告病例。虽然阴茎骨折的风险可能会随着时间降低，但这些病例表明该风险可能会持续超过4周。
相似文献
1
Late-Onset Penile Fracture After Collagenase Treatment for Peyronie's Disease in a 70-Year-Old Patient.一名70岁患者在接受胶原酶治疗佩罗尼氏病后出现迟发性阴茎骨折。
Case Rep Urol. 2025 Sep 2;2025:2126627. doi: 10.1155/criu/2126627. eCollection 2025.
2
Non-surgical therapies for Peyronie's disease.非手术治疗 Peyronie 病。
Cochrane Database Syst Rev. 2023 Jul 17;7(7):CD012206. doi: 10.1002/14651858.CD012206.pub2.
3
Factors associated with improved curvature outcomes with collagenase clostridium histolyticum for Peyronie's disease: results from a large prospective series.
J Sex Med. 2025 Oct 5;22(10):1799-1807. doi: 10.1093/jsxmed/qdaf213.
4
Are patients undergoing intralesional collagenase Clostridium histolyticum injection therapy for Peyronie's disease compliant? A 7-year analysis from a tertiary care men's health center.接受病灶内注射溶组织梭状芽孢杆菌胶原酶治疗佩罗尼氏病的患者是否依从？来自一家三级医疗男性健康中心的7年分析。
J Sex Med. 2025 May 10;22(5):794-798. doi: 10.1093/jsxmed/qdaf051.
5
Outcomes of collagenase Clostridium histolyticum in men with ventral curvatures: an updated series.胶原酶 Clostridium histolyticum 在男性腹侧弯曲患者中的疗效：一项更新的系列研究。
J Sex Med. 2024 Jan 30;21(2):169-174. doi: 10.1093/jsxmed/qdad167.
6
An illustrated description of a modified collagenase Clostridium histolyticum protocol for Peyronie's disease.一种用于佩罗尼氏病的改良溶组织梭状芽孢杆菌胶原酶方案的图示说明。
J Sex Med. 2024 Dec 1;21(12):1169-1177. doi: 10.1093/jsxmed/qdae134.
7
Lateral herniation during treatment with collagenase Clostridium histolyticum (Xiaflex) for Peyronie's disease.在使用胶原酶（希拉飞®，Xiaflex）治疗阴茎硬结症时发生的外侧疝。
BMC Urol. 2021 Jun 27;21(1):94. doi: 10.1186/s12894-021-00858-9.
8
Intralesional Injection of Collagenase Clostridium histolyticum May Increase the Risk of Late-Onset Penile Fracture.胶原酶注射可能增加迟发性阴茎骨折的风险。
Sex Med Rev. 2018 Apr;6(2):272-278. doi: 10.1016/j.sxmr.2017.07.011. Epub 2017 Oct 12.
9
Assessment of Conservative Combination Therapies for Active and Stable Peyronie's Disease: A Systematic Review and Meta-analysis.主动和稳定型 Peyronie 病的保守联合治疗评估：系统评价和荟萃分析。
Eur Urol Focus. 2022 Sep;8(5):1520-1530. doi: 10.1016/j.euf.2021.12.003. Epub 2021 Dec 17.
10
Clinical safety and effectiveness of collagenase clostridium histolyticum injection in patients with Peyronie's disease: a phase 3 open-label study.溶组织梭状芽孢杆菌胶原酶注射治疗佩罗尼氏病患者的临床安全性和有效性：一项3期开放标签研究。
J Sex Med. 2015 Jan;12(1):248-58. doi: 10.1111/jsm.12731. Epub 2014 Nov 12.
本文引用的文献
1
Risk Factors for Penile Fracture After Intralesional Collagenase Clostridium histolyticum in Peyronie's Disease.《阴茎硬结症患者接受胶原酶注射治疗后发生阴茎骨折的风险因素》。
Urology. 2024 Jan;183:117-120. doi: 10.1016/j.urology.2023.10.019. Epub 2023 Nov 8.
2
A systematic review of non-surgical management in Peyronie's disease.阴茎硬结症非手术治疗的系统评价。
Int J Impot Res. 2023 Sep;35(6):523-532. doi: 10.1038/s41443-022-00633-w. Epub 2022 Oct 26.
3
The Management of Penile Fracture: a Review of the Literature with Special Consideration for Patients Undergoing Collagenase Clostridium Histolyticum Injection Therapy.阴茎骨折的处理：文献复习并特别考虑接受胶原酶注射治疗的患者。
Curr Urol Rep. 2021 Jan 20;22(2):13. doi: 10.1007/s11934-020-01025-7.
4
Intralesional Collagenase Clostridium histolyticum Causes Meaningful Improvement in Men with Peyronie's Disease: Results of a Multi-Institutional Analysis.腔内胶原酶组织溶解疗法治疗男性阴茎硬结症：多中心分析结果。
J Urol. 2019 Apr;201(4):777-782. doi: 10.1097/JU.0000000000000032.
5
Intralesional Injection of Collagenase Clostridium histolyticum May Increase the Risk of Late-Onset Penile Fracture.胶原酶注射可能增加迟发性阴茎骨折的风险。
Sex Med Rev. 2018 Apr;6(2):272-278. doi: 10.1016/j.sxmr.2017.07.011. Epub 2017 Oct 12.
6
Current Management of Penile Fracture: An Up-to-Date Systematic Review.阴茎骨折的当前处理方法：最新系统评价。
Sex Med Rev. 2018 Apr;6(2):253-260. doi: 10.1016/j.sxmr.2017.07.009. Epub 2017 Sep 2.
7
An update of Penile Fractures: Long-term significance of the number of hours elapsed till surgical repair on long-term outcomes.阴茎骨折的最新情况：手术修复前经过的小时数对长期预后的长期意义。
Turk J Urol. 2017 Mar;43(1):25-29. doi: 10.5152/tud.2016.39129. Epub 2017 Jan 6.
8
Peyronie's Disease and Injectable Collagenase Clostridium histolyticum: Safety, Efficacy, and Improvements in Subjective Symptoms.佩罗尼氏病与注射用溶组织梭菌胶原酶：安全性、有效性及主观症状改善情况
Urology. 2016 Aug;94:143-7. doi: 10.1016/j.urology.2016.04.049. Epub 2016 May 17.
9
Results of SMSNA Survey Regarding Complications Following Intralesional Injection Therapy With Collagenase Clostridium Histolyticum for Peyronie's Disease.关于溶组织梭状芽孢杆菌胶原酶病灶内注射治疗佩罗尼氏病后并发症的SMSNA调查结果。
J Sex Med. 2016 Apr;13(4):684-9. doi: 10.1016/j.jsxm.2016.02.105. Epub 2016 Mar 25.
10
The Prevalence of Peyronie's Disease in the United States: A Population-Based Study.美国佩罗尼氏病的患病率：一项基于人群的研究。
PLoS One. 2016 Feb 23;11(2):e0150157. doi: 10.1371/journal.pone.0150157. eCollection 2016.
Zotero 插件